Assembling cell context-specific gene sets: a case in cardiomyopathy

Assembling cell context-specific gene sets: a case in cardiomyopathy

Show other versions (1)

An increasing amount of evidence suggests that canonical pathways and standard molecular signature databases are incomplete and inadequate to model the complex behavior of cell physiology and pathology. Yet, many Gene Set Analysis (GSA) studies still rely on these databases to identify disease bioma...

Full description

Bibliographic Details
Main Authors: Liu Mingming, King Vanessa, Lim Wei Keat
Format: Article
Language:English
Published: De Gruyter 2013-03-01
Series:Journal of Integrative Bioinformatics
Online Access:http://www.degruyter.com/view/j/jib.2013.10.issue-1/biecoll-jib-2013-234/biecoll-jib-2013-234.xml?format=INT
id doaj-b09a3862730549a9a0ebfa53d88dbf6e
record_format Article
spelling doaj-b09a3862730549a9a0ebfa53d88dbf6e2020-11-24T21:55:49ZengDe GruyterJournal of Integrative Bioinformatics1613-45162013-03-01101466110.1515/jib-2013-234biecoll-jib-2013-234Assembling cell context-specific gene sets: a case in cardiomyopathyLiu Mingming0King Vanessa1Lim Wei Keat2Department of Computer Science, Virginia Polytechnic Institute and State University, Blacksburg, VA, United States of AmericaSiemens Corporation, Corporate Technology, Princeton, NJ, United States of AmericaSiemens Corporation, Corporate Technology, Princeton, NJ, United States of AmericaAn increasing amount of evidence suggests that canonical pathways and standard molecular signature databases are incomplete and inadequate to model the complex behavior of cell physiology and pathology. Yet, many Gene Set Analysis (GSA) studies still rely on these databases to identify disease biomarkers and molecular mechanisms within a specific cell context. While tremendous effort has been invested in developing GSA tools, there is limited number of studies focusing on de novo assembly of context-specific gene sets as opposed to simply applying GSA using the standard gene set database.http://www.degruyter.com/view/j/jib.2013.10.issue-1/biecoll-jib-2013-234/biecoll-jib-2013-234.xml?format=INT
collection DOAJ
language English
format Article
sources DOAJ
author Liu Mingming
King Vanessa
Lim Wei Keat
spellingShingle Liu Mingming
King Vanessa
Lim Wei Keat
Assembling cell context-specific gene sets: a case in cardiomyopathy
Journal of Integrative Bioinformatics
author_facet Liu Mingming
King Vanessa
Lim Wei Keat
author_sort Liu Mingming
title Assembling cell context-specific gene sets: a case in cardiomyopathy
title_short Assembling cell context-specific gene sets: a case in cardiomyopathy
title_full Assembling cell context-specific gene sets: a case in cardiomyopathy
title_fullStr Assembling cell context-specific gene sets: a case in cardiomyopathy
title_full_unstemmed Assembling cell context-specific gene sets: a case in cardiomyopathy
title_sort assembling cell context-specific gene sets: a case in cardiomyopathy
publisher De Gruyter
series Journal of Integrative Bioinformatics
issn 1613-4516
publishDate 2013-03-01
description An increasing amount of evidence suggests that canonical pathways and standard molecular signature databases are incomplete and inadequate to model the complex behavior of cell physiology and pathology. Yet, many Gene Set Analysis (GSA) studies still rely on these databases to identify disease biomarkers and molecular mechanisms within a specific cell context. While tremendous effort has been invested in developing GSA tools, there is limited number of studies focusing on de novo assembly of context-specific gene sets as opposed to simply applying GSA using the standard gene set database.
url http://www.degruyter.com/view/j/jib.2013.10.issue-1/biecoll-jib-2013-234/biecoll-jib-2013-234.xml?format=INT
work_keys_str_mv AT liumingming assemblingcellcontextspecificgenesetsacaseincardiomyopathy
AT kingvanessa assemblingcellcontextspecificgenesetsacaseincardiomyopathy
AT limweikeat assemblingcellcontextspecificgenesetsacaseincardiomyopathy
_version_ 1725861211034091520

Similar Items