RNAi induces innate immunity through multiple cellular signaling pathways.

RNAi induces innate immunity through multiple cellular signaling pathways.

BACKGROUND AIMS: Our previous results showed that the knockdown of woodchuck hepatitis virus (WHV) by RNA interference (RNAi) led to upregulation of interferon stimulated genes (ISGs) in primary hepatocytes. In the present study, we tested the hypothesis that the cellular signaling pathways recogniz...

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Bibliographic Details
Main Authors: Zhongji Meng, Xiaoyong Zhang, Jun Wu, Rongjuan Pei, Yang Xu, Dongliang Yang, Michael Roggendorf, Mengji Lu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3659100?pdf=render

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