Density-Dependent Recycling Promotes the Long-Term Survival of Bacterial Populations during Periods of Starvation

• Main Authors: Sotaro Takano, Bogna J. Pawlowska, Ivana Gudelj, Tetsuya Yomo, Saburo Tsuru, Bruce R. Levin
• Format: Article
• Language: English
• Published: American Society for Microbiology 2017-02-01
• Series: mBio
• Online Access: http://mbio.asm.org/cgi/content/full/8/1/e02336-16

The amount of natural resources in the Earth’s environment is in flux, which can trigger catastrophic collapses of ecosystems. How populations survive under nutrient-poor conditions is a central question in ecology. Curiously, some bacteria persist for a long time in nutrient-poor environments. Although this survival may be accomplished through cell death and the recycling of dead cells, the importance of these processes and the mechanisms underlying the survival of the populations have not been quantitated. Here, we use microbial laboratory experiments and mathematical models to demonstrate that death and recycling are essential activities for the maintenance of cell survival. We also show that the behavior of the survivors is governed by population density feedback, wherein growth is limited not only by the available resources but also by the population density. The numerical simulations suggest that population density-dependent recycling could be an advantageous behavior under starvation conditions.