Cholesterol Metabolism: A Potential Therapeutic Target in Glioblastoma

Cholesterol Metabolism: A Potential Therapeutic Target in Glioblastoma

Glioblastoma is a highly lethal adult brain tumor with no effective treatments. In this review, we discuss the potential to target cholesterol metabolism as a new strategy for treating glioblastomas. Twenty percent of cholesterol in the body is in the brain, yet the brain is unique among organs in t...

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Bibliographic Details
Main Authors:	Fahim Ahmad, Qian Sun, Deven Patel, Jayne M. Stommel
Format:	Article
Language:	English
Published:	MDPI AG 2019-01-01
Series:	Cancers
Subjects:	glioblastoma cholesterol liver X receptor (LXR) brain liver metabolism blood–brain barrier low-density lipoprotein receptor (LDLR) sterol regulatory element binding protein (SREBP)
Online Access:	https://www.mdpi.com/2072-6694/11/2/146

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