Possible Association of HLA-DR and DQ Molecules with Autoimmune Hepatitis in Iraqi Patients

• Main Authors: Eman Sh. AL-Obeidy, Khalida M. Mousawy, Raghad J H AL-Akayshi, Laith Abdalelah
• Format: Article
• Language: English
• Published: Faculty of Medicine University of Baghdad 2010-04-01
• Series: مجلة كلية الطب
• Subjects: autoimmune hepatitis, Human leukocyte antigen (HLA), PCR –SSP assay.
• Online Access: http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/1057

Background: Human leukocyte antigen (HLA) is the most polymorphic genetic system in man. The genes of this region seem to influence susceptibility to certain diseases. Patients and methods: Polymerase chain reaction-Sequence Specific Primers PCR-SSP is the method used to asses HLA-typing of 100 blood samples of 60 AIH patients and 40 healthy normal controls. Results: An increased frequency of HLA-DR3, DR4 and DR7 was observed for patients group versus control group with P-value (0.0001, 0.05, and 0.001) respectively, while DR*0211 (DR2) may be formed the basis for protection against the disease. HLA-DQ on the other hand, yielded on association in Iraqi patients with AIH. Conclusions: This finding demonstrated that HLA-DR3, DR4 and DR7 might play a role in AIH susceptibility.