CORRELATION BETWEEN PULSE PRESSURE (MEAN VALUE OVER 24 HOURS) AND CHRONIC KIDNEY DISEASE IN HYPERTENSIVE PATIENTS

• Main Authors: Alexandru Mincă, Maria Daniela Tănăsescu, Andra Elena Balcangiu-Stroescu, Alexandru Diaconescu, Delia Timofte, Ciprian Alexandru Boţocan, Laura Răducu, Dorin Dragoş, Dorin Ionescu, Mircea Nicolae Penescu
• Format: Article
• Language: English
• Published: Amaltea Medical Publishing House 2019-06-01
• Series: Romanian Medical Journal
• Subjects: chronic kidney disease; hypertension; pulse pressure; ambulatory blood pressure monitoring; cardiovascular risk
• Online Access: https://revistemedicale.amaltea.ro/Romanian_MEDICAL_Journal/Revista_MEDICALA_ROMANA-2019-Nr.2/RMJ_2019_2_Art-07.pdf
• ISSN: 1220-5478; 2069-606X

The aim of this study is to evaluate the presence / absence of the correlation between pulse pressure (PP, determined by ambulatory blood pressure monitoring (ABPM)) and traditional and non-traditional cardiovascular (CV) risk factors: age, sex, blood glucose, proteinuria / microalbuminuria, uric acid, ESR, fibrinogen, total cholesterol, HDL – cholesterol), triglyceridemia, Hb, in renal and non-renal hypertensive patients. Material and method. The data were collected from the observation records of 412 hypertensive patients admitted during the period 2006-2012 to the Department of Nephrology and Internal Medicine 1 of the Bucharest Emergency University Hospital. It is a retrospective study. These data consist of blood and urine analysis, on the one hand, and parameters obtained by ABPM, on the other hand. The subjects were divided into two groups: hypertensive patients with and without CKD. The results of the study showed a positive correlation between the presence of CKD and mean 24-hour PP with a statistical effect (p <0.01): mean PP was in the first group 63.04 ± 15.53 mmHg versus 53.40 ± 12, 29 mmHg in the group of patients without CKD. The result is also maintained in multivariate analysis. Discussions. Study limitations are the following: the relatively small group of subjects to issue valid population conclusions, we could not control the multiple variables involved in cardiovascular risk, and the fact that subjects included in the study are not followed for a longer period of time. Conclusions. Based on the results obtained, it can be concluded that the presence of CKD determines the increase of the cardiovascular risk of the patients. This is due in part to the fact that we found higher mean PP in the group of hypertensive patients with CKD. For a better understanding of this relation further studies are required.