Dirofilaria immitis Microfilariae and Third-Stage Larvae Induce Canine NETosis Resulting in Different Types of Neutrophil Extracellular Traps

Dirofilaria immitis Microfilariae and Third-Stage Larvae Induce Canine NETosis Resulting in Different Types of Neutrophil Extracellular Traps

Heartworm disease is a zoonotic vector-borne disease caused by Dirofilaria immitis mainly affecting canids. Infectious third-stage larvae (L3) are transmitted to the definitive hosts via culicid mosquitoes; adult nematodes reside in the pulmonary arteries and in the right heart releasing unsheathed...

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Bibliographic Details
Main Authors: Tamara Muñoz-Caro, Iván Conejeros, Ershun Zhou, Anton Pikhovych, Ulrich Gärtner, Carlos Hermosilla, Daniel Kulke, Anja Taubert
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Immunology
Subjects:
Dirofilaria immitis
neutrophil extracellular traps
innate immunity
NETosis
canine polymorphonuclear neutrophils
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.00968/full

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