Generation of the First Structure-Based Pharmacophore Model Containing a Selective “Zinc Binding Group” Feature to Identify Potential Glyoxalase-1 Inhibitors

Within this study, a unique 3D structure-based pharmacophore model of the enzyme glyoxalase-1 (Glo-1) has been revealed. Glo-1 is considered a zinc metalloenzyme in which the inhibitor binding with zinc atom at the active site is crucial. To our knowledge, this is the first pharmacophore model that...

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Bibliographic Details
Main Authors: Qosay Al-Balas, Mohammad Hassan, Buthina Al-Oudat, Hassan Alzoubi, Nizar Mhaidat, Ammar Almaaytah
Format: Article
Language:English
Published: MDPI AG 2012-11-01
Series:Molecules
Subjects:
Online Access:http://www.mdpi.com/1420-3049/17/12/13740