Mechanism of filament nucleation and branch stability revealed by the structure of the Arp2/3 complex at actin branch junctions.
Actin branch junctions are conserved cytoskeletal elements critical for the generation of protrusive force during actin polymerization-driven cellular motility. Assembly of actin branch junctions requires the Arp2/3 complex, upon activation, to initiate a new actin (daughter) filament branch from th...
| Format: | Article |
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| Language: | English |
| Published: |
Public Library of Science (PLoS)
2005-11-01
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| Series: | PLoS Biology |
| Online Access: | http://dx.doi.org/10.1371/journal.pbio.0030383 |