Effect of intravitreal anti-vascular endothelial growth factor on corneal endothelial cell count and central corneal thickness in Indian population

Purpose: To evaluate the effect of intravitreal anti-VEGF on corneal endothelial cell count and central corneal thickness as well as to compare these in phakic and pseudophakic eyes. Material and Methods: The study was conducted in 102 eyes selected, as per selection criteria, over a time period of...

Full description

Bibliographic Details
Main Authors: Mukesh Joshi, Mayuresh P Naik, L Sarkar
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2019-01-01
Series:Journal of Family Medicine and Primary Care
Subjects:
Online Access:http://www.jfmpc.com/article.asp?issn=2249-4863;year=2019;volume=8;issue=7;spage=2429;epage=2432;aulast=Joshi
id doaj-b03ebfce4ca74e3c86d874d570f4a095
record_format Article
spelling doaj-b03ebfce4ca74e3c86d874d570f4a0952020-11-24T21:52:02ZengWolters Kluwer Medknow PublicationsJournal of Family Medicine and Primary Care2249-48632019-01-01872429243210.4103/jfmpc.jfmpc_314_19Effect of intravitreal anti-vascular endothelial growth factor on corneal endothelial cell count and central corneal thickness in Indian populationMukesh JoshiMayuresh P NaikL SarkarPurpose: To evaluate the effect of intravitreal anti-VEGF on corneal endothelial cell count and central corneal thickness as well as to compare these in phakic and pseudophakic eyes. Material and Methods: The study was conducted in 102 eyes selected, as per selection criteria, over a time period of 18 months. At first patient visit, examination included: 1. Fundus examination. 2. Specular microscopy was done to look for endothelial cell count and Central corneal thickness. At second visit, Injection 0.5 mg/0.05 ml of ranibizumab was administered. Visits at day 1, day 7 and 1 month were done for Endothelial cell density and central corneal thickness was measured by specular microscope Results: The mean CCT value in pseudophakic group was 502.08 ± 19.91, 501.9 ± 20.31, and 501.72 ± 21.55 on day 1, 7 and 30, respectively. The mean CCT value in phakic group was 506.53 ± 22.61, 505.96 ± 20.12, 505.92 ± 20.3 and 505.69 ± 21.47. The mean value of ECD in pseudophakic eyes on day 1, 7, and 30 were 2284.24 ± 299.86, 2281.39 ± 289.46 and 2284.06 ± 312.65 cells/mm2, respectively. The mean value of ECD in phakic eyes on day 1, 7, and 30 were 2314.51 ± 212.08, 2313.92 ± 212.7 and 2313.63 ± 216.86 cells/mm2, respectively. Conclusion: There is no significant change in endothelial cell density, central corneal thickness, coefficient of variation and intraocular pressure before and after intravitreal injection over one month of follow-up. The results are similar between phakic and pseudophakic eyes.http://www.jfmpc.com/article.asp?issn=2249-4863;year=2019;volume=8;issue=7;spage=2429;epage=2432;aulast=JoshiAnti-VEGFcentral corneal thicknessendothelial cell count
collection DOAJ
language English
format Article
sources DOAJ
author Mukesh Joshi
Mayuresh P Naik
L Sarkar
spellingShingle Mukesh Joshi
Mayuresh P Naik
L Sarkar
Effect of intravitreal anti-vascular endothelial growth factor on corneal endothelial cell count and central corneal thickness in Indian population
Journal of Family Medicine and Primary Care
Anti-VEGF
central corneal thickness
endothelial cell count
author_facet Mukesh Joshi
Mayuresh P Naik
L Sarkar
author_sort Mukesh Joshi
title Effect of intravitreal anti-vascular endothelial growth factor on corneal endothelial cell count and central corneal thickness in Indian population
title_short Effect of intravitreal anti-vascular endothelial growth factor on corneal endothelial cell count and central corneal thickness in Indian population
title_full Effect of intravitreal anti-vascular endothelial growth factor on corneal endothelial cell count and central corneal thickness in Indian population
title_fullStr Effect of intravitreal anti-vascular endothelial growth factor on corneal endothelial cell count and central corneal thickness in Indian population
title_full_unstemmed Effect of intravitreal anti-vascular endothelial growth factor on corneal endothelial cell count and central corneal thickness in Indian population
title_sort effect of intravitreal anti-vascular endothelial growth factor on corneal endothelial cell count and central corneal thickness in indian population
publisher Wolters Kluwer Medknow Publications
series Journal of Family Medicine and Primary Care
issn 2249-4863
publishDate 2019-01-01
description Purpose: To evaluate the effect of intravitreal anti-VEGF on corneal endothelial cell count and central corneal thickness as well as to compare these in phakic and pseudophakic eyes. Material and Methods: The study was conducted in 102 eyes selected, as per selection criteria, over a time period of 18 months. At first patient visit, examination included: 1. Fundus examination. 2. Specular microscopy was done to look for endothelial cell count and Central corneal thickness. At second visit, Injection 0.5 mg/0.05 ml of ranibizumab was administered. Visits at day 1, day 7 and 1 month were done for Endothelial cell density and central corneal thickness was measured by specular microscope Results: The mean CCT value in pseudophakic group was 502.08 ± 19.91, 501.9 ± 20.31, and 501.72 ± 21.55 on day 1, 7 and 30, respectively. The mean CCT value in phakic group was 506.53 ± 22.61, 505.96 ± 20.12, 505.92 ± 20.3 and 505.69 ± 21.47. The mean value of ECD in pseudophakic eyes on day 1, 7, and 30 were 2284.24 ± 299.86, 2281.39 ± 289.46 and 2284.06 ± 312.65 cells/mm2, respectively. The mean value of ECD in phakic eyes on day 1, 7, and 30 were 2314.51 ± 212.08, 2313.92 ± 212.7 and 2313.63 ± 216.86 cells/mm2, respectively. Conclusion: There is no significant change in endothelial cell density, central corneal thickness, coefficient of variation and intraocular pressure before and after intravitreal injection over one month of follow-up. The results are similar between phakic and pseudophakic eyes.
topic Anti-VEGF
central corneal thickness
endothelial cell count
url http://www.jfmpc.com/article.asp?issn=2249-4863;year=2019;volume=8;issue=7;spage=2429;epage=2432;aulast=Joshi
work_keys_str_mv AT mukeshjoshi effectofintravitrealantivascularendothelialgrowthfactoroncornealendothelialcellcountandcentralcornealthicknessinindianpopulation
AT mayureshpnaik effectofintravitrealantivascularendothelialgrowthfactoroncornealendothelialcellcountandcentralcornealthicknessinindianpopulation
AT lsarkar effectofintravitrealantivascularendothelialgrowthfactoroncornealendothelialcellcountandcentralcornealthicknessinindianpopulation
_version_ 1725877258575413248