Interplay of active processes modulates tension and drives phase transition in self-renewing, motor-driven cytoskeletal networks

Interplay of active processes modulates tension and drives phase transition in self-renewing, motor-driven cytoskeletal networks

The actin cytoskeleton is a complex network of filaments, cross-linking proteins and motors; although the components are recognised, the behaviour of the network is less understood. Here Mak et al.use a Brownian dynamics model that reveals actin turnover dynamics as a key regulatory mechanism contro...

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Main Authors: Michael Mak, Muhammad H. Zaman, Roger D. Kamm, Taeyoon Kim
Format: Article
Language:English
Published: Nature Publishing Group 2016-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms10323
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spelling doaj-b03a6e4804b340c98616e8218780f4942021-05-11T11:08:02ZengNature Publishing GroupNature Communications2041-17232016-01-017111210.1038/ncomms10323Interplay of active processes modulates tension and drives phase transition in self-renewing, motor-driven cytoskeletal networksMichael Mak0Muhammad H. Zaman1Roger D. Kamm2Taeyoon Kim3Department of Mechanical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USADepartment of Biomedical Engineering, Boston University, 44 Cummington Mall, Boston, Massachusetts 02215, USADepartment of Mechanical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USAWeldon School of Biomedical Engineering, Purdue University, 206 S. Martin Jischke Drive, West Lafayette, Indiana 47907, USAThe actin cytoskeleton is a complex network of filaments, cross-linking proteins and motors; although the components are recognised, the behaviour of the network is less understood. Here Mak et al.use a Brownian dynamics model that reveals actin turnover dynamics as a key regulatory mechanism controlling cytoskeletal states.https://doi.org/10.1038/ncomms10323
collection DOAJ
language English
format Article
sources DOAJ
author Michael Mak
Muhammad H. Zaman
Roger D. Kamm
Taeyoon Kim
spellingShingle Michael Mak
Muhammad H. Zaman
Roger D. Kamm
Taeyoon Kim
Interplay of active processes modulates tension and drives phase transition in self-renewing, motor-driven cytoskeletal networks
Nature Communications
author_facet Michael Mak
Muhammad H. Zaman
Roger D. Kamm
Taeyoon Kim
author_sort Michael Mak
title Interplay of active processes modulates tension and drives phase transition in self-renewing, motor-driven cytoskeletal networks
title_short Interplay of active processes modulates tension and drives phase transition in self-renewing, motor-driven cytoskeletal networks
title_full Interplay of active processes modulates tension and drives phase transition in self-renewing, motor-driven cytoskeletal networks
title_fullStr Interplay of active processes modulates tension and drives phase transition in self-renewing, motor-driven cytoskeletal networks
title_full_unstemmed Interplay of active processes modulates tension and drives phase transition in self-renewing, motor-driven cytoskeletal networks
title_sort interplay of active processes modulates tension and drives phase transition in self-renewing, motor-driven cytoskeletal networks
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2016-01-01
description The actin cytoskeleton is a complex network of filaments, cross-linking proteins and motors; although the components are recognised, the behaviour of the network is less understood. Here Mak et al.use a Brownian dynamics model that reveals actin turnover dynamics as a key regulatory mechanism controlling cytoskeletal states.
url https://doi.org/10.1038/ncomms10323
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AT muhammadhzaman interplayofactiveprocessesmodulatestensionanddrivesphasetransitioninselfrenewingmotordrivencytoskeletalnetworks
AT rogerdkamm interplayofactiveprocessesmodulatestensionanddrivesphasetransitioninselfrenewingmotordrivencytoskeletalnetworks
AT taeyoonkim interplayofactiveprocessesmodulatestensionanddrivesphasetransitioninselfrenewingmotordrivencytoskeletalnetworks
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