Synchronous Breast Implant–associated Anaplastic Large Cell Lymphoma and Invasive Carcinoma: Genomic Profiling and Management Implications
SUMMARY:. A 59-year-old woman with a history of cosmetic implants developed ipsilateral synchronous breast implant–associated anaplastic large cell lymphoma (BIA-ALCL) and invasive ductal carcinoma in the left breast. Each tumor was subjected to next-generation sequencing, and separate analyses reve...
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Wolters Kluwer
2019-04-01
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| Series: | Plastic and Reconstructive Surgery, Global Open |
| Online Access: | http://journals.lww.com/prsgo/fulltext/10.1097/GOX.0000000000002188 |
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doaj-b039f24562884db295787122a1b5cf5c2020-11-25T02:14:47ZengWolters KluwerPlastic and Reconstructive Surgery, Global Open2169-75742019-04-0174e218810.1097/GOX.0000000000002188201904000-00004Synchronous Breast Implant–associated Anaplastic Large Cell Lymphoma and Invasive Carcinoma: Genomic Profiling and Management ImplicationsRita A. Mukhtar, MD0Michael Holland, MD1David A. Sieber, MD2Kwun Wah Wen, MD, PhD3Hope S. Rugo, MD4Marshall E. Kadin, MD5Gregory R. Bean, MD, PhD6From the *Department of Surgery, University of California San Francisco, San Francisco, Calif.From the *Department of Surgery, University of California San Francisco, San Francisco, Calif.†Sieber Plastic Surgery, San Francisco, Calif.‡Department of Pathology, University of California San Francisco, San Francisco, Calif.§Helen Diller Family Comprehensive Cancer Center, University of California San Francisco; San Francisco, Calif.¶Department of Dermatology and Skin Surgery, Boston University School of Medicine; Boston, Mass.**Department of Pathology, Stanford University School of Medicine, Stanford, Calif.SUMMARY:. A 59-year-old woman with a history of cosmetic implants developed ipsilateral synchronous breast implant–associated anaplastic large cell lymphoma (BIA-ALCL) and invasive ductal carcinoma in the left breast. Each tumor was subjected to next-generation sequencing, and separate analyses revealed mutually exclusive aberrations: an activating STAT3 mutation in the lymphoma and a PIK3CA in-frame deletion in the carcinoma. The patient was treated with removal of implants, capsulectomy, partial mastectomy, sentinel node biopsy, radiotherapy, and endocrine therapy with no evidence of recurrence for 1 year. This case illustrates the importance of obtaining thorough evaluation for concomitant malignancies in the breast at the time of diagnosis of BIA-ALCL. Herein, we review the current recommendations for evaluation and management of BIA-ALCL.http://journals.lww.com/prsgo/fulltext/10.1097/GOX.0000000000002188 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Rita A. Mukhtar, MD Michael Holland, MD David A. Sieber, MD Kwun Wah Wen, MD, PhD Hope S. Rugo, MD Marshall E. Kadin, MD Gregory R. Bean, MD, PhD |
| spellingShingle |
Rita A. Mukhtar, MD Michael Holland, MD David A. Sieber, MD Kwun Wah Wen, MD, PhD Hope S. Rugo, MD Marshall E. Kadin, MD Gregory R. Bean, MD, PhD Synchronous Breast Implant–associated Anaplastic Large Cell Lymphoma and Invasive Carcinoma: Genomic Profiling and Management Implications Plastic and Reconstructive Surgery, Global Open |
| author_facet |
Rita A. Mukhtar, MD Michael Holland, MD David A. Sieber, MD Kwun Wah Wen, MD, PhD Hope S. Rugo, MD Marshall E. Kadin, MD Gregory R. Bean, MD, PhD |
| author_sort |
Rita A. Mukhtar, MD |
| title |
Synchronous Breast Implant–associated Anaplastic Large Cell Lymphoma and Invasive Carcinoma: Genomic Profiling and Management Implications |
| title_short |
Synchronous Breast Implant–associated Anaplastic Large Cell Lymphoma and Invasive Carcinoma: Genomic Profiling and Management Implications |
| title_full |
Synchronous Breast Implant–associated Anaplastic Large Cell Lymphoma and Invasive Carcinoma: Genomic Profiling and Management Implications |
| title_fullStr |
Synchronous Breast Implant–associated Anaplastic Large Cell Lymphoma and Invasive Carcinoma: Genomic Profiling and Management Implications |
| title_full_unstemmed |
Synchronous Breast Implant–associated Anaplastic Large Cell Lymphoma and Invasive Carcinoma: Genomic Profiling and Management Implications |
| title_sort |
synchronous breast implant–associated anaplastic large cell lymphoma and invasive carcinoma: genomic profiling and management implications |
| publisher |
Wolters Kluwer |
| series |
Plastic and Reconstructive Surgery, Global Open |
| issn |
2169-7574 |
| publishDate |
2019-04-01 |
| description |
SUMMARY:. A 59-year-old woman with a history of cosmetic implants developed ipsilateral synchronous breast implant–associated anaplastic large cell lymphoma (BIA-ALCL) and invasive ductal carcinoma in the left breast. Each tumor was subjected to next-generation sequencing, and separate analyses revealed mutually exclusive aberrations: an activating STAT3 mutation in the lymphoma and a PIK3CA in-frame deletion in the carcinoma. The patient was treated with removal of implants, capsulectomy, partial mastectomy, sentinel node biopsy, radiotherapy, and endocrine therapy with no evidence of recurrence for 1 year. This case illustrates the importance of obtaining thorough evaluation for concomitant malignancies in the breast at the time of diagnosis of BIA-ALCL. Herein, we review the current recommendations for evaluation and management of BIA-ALCL. |
| url |
http://journals.lww.com/prsgo/fulltext/10.1097/GOX.0000000000002188 |
| work_keys_str_mv |
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