The ETS transcription factor ELF1 regulates a broadly antiviral program distinct from the type I interferon response.

The ETS transcription factor ELF1 regulates a broadly antiviral program distinct from the type I interferon response.

Induction of vast transcriptional programs is a central event of innate host responses to viral infections. Here we report a transcriptional program with potent antiviral activity, driven by E74-like ETS transcription factor 1 (ELF1). Using microscopy to quantify viral infection over time, we found...

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Bibliographic Details
Main Authors: Leon Louis Seifert, Clara Si, Debjani Saha, Mohammad Sadic, Maren de Vries, Sarah Ballentine, Aaron Briley, Guojun Wang, Ana M Valero-Jimenez, Adil Mohamed, Uwe Schaefer, Hong M Moulton, Adolfo García-Sastre, Shashank Tripathi, Brad R Rosenberg, Meike Dittmann
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-11-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1007634

Internet

https://doi.org/10.1371/journal.ppat.1007634

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