Mechanism of karyopherin-β2 binding and nuclear import of ALS variants FUS(P525L) and FUS(R495X)

Mechanism of karyopherin-β2 binding and nuclear import of ALS variants FUS(P525L) and FUS(R495X)

Abstract Mutations in the RNA-binding protein FUS cause familial amyotropic lateral sclerosis (ALS). Several mutations that affect the proline-tyrosine nuclear localization signal (PY-NLS) of FUS cause severe juvenile ALS. FUS also undergoes liquid–liquid phase separation (LLPS) to accumulate in str...

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Bibliographic Details
Main Authors: Abner Gonzalez, Taro Mannen, Tolga Çağatay, Ayano Fujiwara, Hiroyoshi Matsumura, Ashley B. Niesman, Chad A. Brautigam, Yuh Min Chook, Takuya Yoshizawa
Format: Article
Language:English
Published: Nature Publishing Group 2021-02-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-83196-y

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https://doi.org/10.1038/s41598-021-83196-y

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