Conditional Deletion of EphA4 on Cx3cr1-Expressing Microglia Fails to Influence Histopathological Outcome and Blood Brain Barrier Disruption Following Brain Injury

Conditional Deletion of EphA4 on Cx3cr1-Expressing Microglia Fails to Influence Histopathological Outcome and Blood Brain Barrier Disruption Following Brain Injury

Erythropoietin-producing human hepatocellular receptors play a major role in central nervous system injury. Preclinical and clinical studies revealed the upregulation of erythropoietin-producing human hepatocellular A4 (EphA4) receptors in the brain after acute traumatic brain injury. We have previo...

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Bibliographic Details
Main Authors: Eman Soliman, Jatia Mills, Jing Ju, Alexandra M. Kaloss, Erwin Kristobal Gudenschwager Basso, Nathalie Groot, Colin Kelly, Elizabeth A. Kowalski, Mohamed Elhassanny, Michael Chen, Xia Wang, Michelle H. Theus
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Molecular Neuroscience
Subjects:
neuroinflammation
TMEM119
peripheral monocytes
Eph signaling
innate immune
traumatic brain injury
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2021.747770/full

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