Diffusive tail anchorage determines velocity and force produced by kinesin-14 between crosslinked microtubules

Diffusive tail anchorage determines velocity and force produced by kinesin-14 between crosslinked microtubules

Kinesin-14s, such as Ncd, interact with microtubules with their non-processive motor domains and their diffusive tail domains, but the influence of the tail domains on motor performance is not known. Here the authors show that tail domain slippage limits the velocities and forces generated by Ncd, s...

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Main Authors: Annemarie Lüdecke, Anja-Maria Seidel, Marcus Braun, Zdenek Lansky, Stefan Diez
Format: Article
Language:English
Published: Nature Publishing Group 2018-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-04656-0
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spelling doaj-b025a17c0c624b77839a6abd8efb96b02021-05-11T09:21:52ZengNature Publishing GroupNature Communications2041-17232018-06-01911910.1038/s41467-018-04656-0Diffusive tail anchorage determines velocity and force produced by kinesin-14 between crosslinked microtubulesAnnemarie Lüdecke0Anja-Maria Seidel1Marcus Braun2Zdenek Lansky3Stefan Diez4B CUBE–Center for Molecular Bioengineering, Technische Universität DresdenB CUBE–Center for Molecular Bioengineering, Technische Universität DresdenB CUBE–Center for Molecular Bioengineering, Technische Universität DresdenB CUBE–Center for Molecular Bioengineering, Technische Universität DresdenB CUBE–Center for Molecular Bioengineering, Technische Universität DresdenKinesin-14s, such as Ncd, interact with microtubules with their non-processive motor domains and their diffusive tail domains, but the influence of the tail domains on motor performance is not known. Here the authors show that tail domain slippage limits the velocities and forces generated by Ncd, suggesting it acts as a slippery crosslinker.https://doi.org/10.1038/s41467-018-04656-0
collection DOAJ
language English
format Article
sources DOAJ
author Annemarie Lüdecke
Anja-Maria Seidel
Marcus Braun
Zdenek Lansky
Stefan Diez
spellingShingle Annemarie Lüdecke
Anja-Maria Seidel
Marcus Braun
Zdenek Lansky
Stefan Diez
Diffusive tail anchorage determines velocity and force produced by kinesin-14 between crosslinked microtubules
Nature Communications
author_facet Annemarie Lüdecke
Anja-Maria Seidel
Marcus Braun
Zdenek Lansky
Stefan Diez
author_sort Annemarie Lüdecke
title Diffusive tail anchorage determines velocity and force produced by kinesin-14 between crosslinked microtubules
title_short Diffusive tail anchorage determines velocity and force produced by kinesin-14 between crosslinked microtubules
title_full Diffusive tail anchorage determines velocity and force produced by kinesin-14 between crosslinked microtubules
title_fullStr Diffusive tail anchorage determines velocity and force produced by kinesin-14 between crosslinked microtubules
title_full_unstemmed Diffusive tail anchorage determines velocity and force produced by kinesin-14 between crosslinked microtubules
title_sort diffusive tail anchorage determines velocity and force produced by kinesin-14 between crosslinked microtubules
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-06-01
description Kinesin-14s, such as Ncd, interact with microtubules with their non-processive motor domains and their diffusive tail domains, but the influence of the tail domains on motor performance is not known. Here the authors show that tail domain slippage limits the velocities and forces generated by Ncd, suggesting it acts as a slippery crosslinker.
url https://doi.org/10.1038/s41467-018-04656-0
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AT anjamariaseidel diffusivetailanchoragedeterminesvelocityandforceproducedbykinesin14betweencrosslinkedmicrotubules
AT marcusbraun diffusivetailanchoragedeterminesvelocityandforceproducedbykinesin14betweencrosslinkedmicrotubules
AT zdeneklansky diffusivetailanchoragedeterminesvelocityandforceproducedbykinesin14betweencrosslinkedmicrotubules
AT stefandiez diffusivetailanchoragedeterminesvelocityandforceproducedbykinesin14betweencrosslinkedmicrotubules
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