Characterization of Binding Properties of Individual Functional Sites of Human Complement Factor H

Characterization of Binding Properties of Individual Functional Sites of Human Complement Factor H

Factor H exists as a 155,000 dalton, extended protein composed of twenty small domains which is flexible enough that it folds back on itself. Factor H regulates complement activation through its interactions with C3b and polyanions. Three binding sites for C3b and multiple polyanion binding sites ha...

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Bibliographic Details
Main Authors: Aftabul Haque, Claudio Cortes, M. Nurul Alam, Maladi Sreedhar, Viviana P. Ferreira, Michael K. Pangburn
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Immunology
Subjects:
complement
Complement Factor H
immunology
innate immunity
protein expression
structure-function
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01728/full

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