Initial Characterization of Stressed Transgenic Mice With Cardiomyocyte-Specific Overexpression of Protein Phosphatase 2C

Initial Characterization of Stressed Transgenic Mice With Cardiomyocyte-Specific Overexpression of Protein Phosphatase 2C

As part of our ongoing studies on the potential pathophysiological role of serine/threonine phosphatases (PP) in the mammalian heart, we have generated mice with cardiac-specific overexpression of PP2Cβ (PP2C-TG) and compared them with littermate wild type mice (WT) serving as a control. Cardiac fib...

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Bibliographic Details
Main Authors: Paula Bollmann, Franziska Werner, Marko Jaron, Tom A. Bruns, Hartmut Wache, Jochen Runte, Peter Boknik, Uwe Kirchhefer, Frank U. Müller, Igor B. Buchwalow, Sven Rothemund, Joachim Neumann, Ulrich Gergs
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Pharmacology
Subjects:
transgenic mice
PP2A
PP2C
heart failure
fibrosis
inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2020.591773/full

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