Mechanism mediating oligomeric Aβ clearance by naïve primary microglia

Mechanism mediating oligomeric Aβ clearance by naïve primary microglia

The accumulation of soluble oligomeric amyloid-β peptide (oAβ) proceeds the formation of senile plaques and contributes to synaptic and memory deficits in Alzheimer's disease (AD). The mechanism of mediating microglial oAβ clearance remains unclear and thought to occur via scavenger receptors...

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Bibliographic Details
Main Authors:	Cheng-Ning Yang, Young-Ji Shiao, Feng-Shiun Shie, Bo-Shen Guo, Pei-Hao Chen, Chi-Yuan Cho, Yi-Jen Chen, Fong-Lee Huang, Huey-Jen Tsay
Format:	Article
Language:	English
Published:	Elsevier 2011-06-01
Series:	Neurobiology of Disease
Subjects:	Beta-amyloid Alzheimer's disease Scavenger receptors Lysosomal degradation
Online Access:	http://www.sciencedirect.com/science/article/pii/S0969996111000064

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