Protection from systemic pyruvate at resuscitation in newborn lambs with asphyxial cardiac arrest

Protection from systemic pyruvate at resuscitation in newborn lambs with asphyxial cardiac arrest

Abstract Background Infants with hypoxic‐ischemic injury often require cardiopulmonary resuscitation. Mitochondrial failure to generate adenosine triphosphate (ATP) during hypoxic‐ischemic reperfusion injury contributes to cellular damage. Current postnatal strategies to improve outcome in hypoxic‐i...

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Bibliographic Details
Main Authors: Vasantha H. S. Kumar, Sylvia Gugino, Lori Nielsen, Praveen Chandrasekharan, Carmon Koenigsknecht, Justin Helman, Satyan Lakshminrusimha
Format: Article
Language:English
Published: Wiley 2020-06-01
Series:Physiological Reports
Subjects:
ATP
cardiac arrest
CMRO2
hypoxic‐ischemic injury
newborns
pyruvate
Online Access:https://doi.org/10.14814/phy2.14472

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