C subunit of the ATP synthase is an amyloidogenic calcium dependent channel-forming peptide with possible implications in mitochondrial permeability transition

C subunit of the ATP synthase is an amyloidogenic calcium dependent channel-forming peptide with possible implications in mitochondrial permeability transition

Abstract The c subunit is an inner mitochondrial membrane (IMM) protein encoded by three nuclear genes. Best known as an integral part of the F0 complex of the ATP synthase, the c subunit is also present in other cytoplasmic compartments in ceroid lipofuscinoses. Under physiological conditions, this...

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Bibliographic Details
Main Authors: Giuseppe Federico Amodeo, Brenda Yasie Lee, Natalya Krilyuk, Carina Teresa Filice, Denis Valyuk, Daniel Erik Otzen, Sergey Noskov, Zoya Leonenko, Evgeny V. Pavlov
Format: Article
Language:English
Published: Nature Publishing Group 2021-04-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-88157-z

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https://doi.org/10.1038/s41598-021-88157-z

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