Cellular cartography of the organ of Corti based on optical tissue clearing and machine learning

Cellular cartography of the organ of Corti based on optical tissue clearing and machine learning

The highly organized spatial arrangement of sensory hair cells in the organ of Corti is essential for inner ear function. Here, we report a new analytical pipeline, based on optical clearing of tissue, for the construction of a single-cell resolution map of the organ of Corti. A sorbitol-based optic...

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Bibliographic Details
Main Authors: Shinji Urata, Tadatsune Iida, Masamichi Yamamoto, Yu Mizushima, Chisato Fujimoto, Yu Matsumoto, Tatsuya Yamasoba, Shigeo Okabe
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-01-01
Series:eLife
Subjects:
organ of Corti
optical tissue clearing
hair cell
hearing loss
hard tissue
machine learning
Online Access:https://elifesciences.org/articles/40946

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