Mesenchymal Stem Cell Secretion of SDF-1α Modulates Endothelial Function in Dilated Cardiomyopathy

Mesenchymal Stem Cell Secretion of SDF-1α Modulates Endothelial Function in Dilated Cardiomyopathy

BackgroundEndothelial dysfunction contributes to the pathophysiology of dilated cardiomyopathy (DCM). Allogeneic but not autologous mesenchymal stem cells (MSCs) improve endothelial function in DCM patients. We hypothesized that these effects are modulated by release of stromal derived factor-1α (SD...

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Bibliographic Details
Main Authors: Courtney Premer, Amarylis Wanschel, Valeria Porras, Wayne Balkan, Tatiana Legendre-Hyldig, Russell G. Saltzman, Chunming Dong, Ivonne Hernandez Schulman, Joshua M. Hare
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Physiology
Subjects:
endothelial dysfunction
mesenchymal stem cells
allogeneic
dilated cardiomyopathy
SDF 1α
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2019.01182/full

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