New Isoflavanes from <i>Spatholobus suberectus</i> and Their Cytotoxicity against Human Breast Cancer Cell Lines

The rattans of <i>Spatholobus suberectus</i> Dunn are a traditional Chinese medicine activating blood circulation and removing stasis. They have often been used for the traditional Chinese medicinal treatment of breast cancer in modern China. In this study, four novel isoflavanes (<b&...

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Main Authors:	Fu Peng, Huan Zhu, Chun-Wang Meng, Yan-Rui Ren, Ou Dai, Liang Xiong
Format:	Article
Language:	English
Published:	MDPI AG 2019-09-01
Series:	Molecules
Subjects:	<i>Spatholobus suberectus</i> isoflavanes breast cancer MCF-7 MDA-MB-231
Online Access:	https://www.mdpi.com/1420-3049/24/18/3218

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spelling	doaj-aff3f50c5a7f4fd3a5ea593d72a90c8d2020-11-25T01:01:40ZengMDPI AGMolecules1420-30492019-09-012418321810.3390/molecules24183218molecules24183218New Isoflavanes from <i>Spatholobus suberectus</i> and Their Cytotoxicity against Human Breast Cancer Cell LinesFu Peng0Huan Zhu1Chun-Wang Meng2Yan-Rui Ren3Ou Dai4Liang Xiong5West China School of Pharmacy, Sichuan University, Chengdu 610041, ChinaSchool of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, ChinaSchool of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, ChinaSchool of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, ChinaSchool of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, ChinaSchool of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, ChinaThe rattans of <i>Spatholobus suberectus</i> Dunn are a traditional Chinese medicine activating blood circulation and removing stasis. They have often been used for the traditional Chinese medicinal treatment of breast cancer in modern China. In this study, four novel isoflavanes (<b>1</b>−<b>3</b> and <b>5</b>) and four known analogues (<b>4</b> and <b>6</b>−<b>8</b>) were isolated from an ethanolic extract of the rattans of <i>S. suberectus</i>. Their structures were elucidated by extensive spectroscopic analyses and electronic circular dichroism studies. MCF-7 and MDA-MB-231 human breast cancer cell lines were used to evaluate the cytotoxic effects of the isolates. Interestingly, compounds <b>1</b> and <b>2</b> only inhibited the proliferation of MCF-7 cells, while compound <b>6</b> showed a selective cytotoxicity against MDA-MB-231 cells. However, compound <b>4</b> had significant cytotoxicity against both MCF-7 and MDA-MB-231 cell lines.https://www.mdpi.com/1420-3049/24/18/3218<i>Spatholobus suberectus</i>isoflavanesbreast cancerMCF-7MDA-MB-231
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Fu Peng Huan Zhu Chun-Wang Meng Yan-Rui Ren Ou Dai Liang Xiong
spellingShingle	Fu Peng Huan Zhu Chun-Wang Meng Yan-Rui Ren Ou Dai Liang Xiong New Isoflavanes from <i>Spatholobus suberectus</i> and Their Cytotoxicity against Human Breast Cancer Cell Lines Molecules <i>Spatholobus suberectus</i> isoflavanes breast cancer MCF-7 MDA-MB-231
author_facet	Fu Peng Huan Zhu Chun-Wang Meng Yan-Rui Ren Ou Dai Liang Xiong
author_sort	Fu Peng
title	New Isoflavanes from <i>Spatholobus suberectus</i> and Their Cytotoxicity against Human Breast Cancer Cell Lines
title_short	New Isoflavanes from <i>Spatholobus suberectus</i> and Their Cytotoxicity against Human Breast Cancer Cell Lines
title_full	New Isoflavanes from <i>Spatholobus suberectus</i> and Their Cytotoxicity against Human Breast Cancer Cell Lines
title_fullStr	New Isoflavanes from <i>Spatholobus suberectus</i> and Their Cytotoxicity against Human Breast Cancer Cell Lines
title_full_unstemmed	New Isoflavanes from <i>Spatholobus suberectus</i> and Their Cytotoxicity against Human Breast Cancer Cell Lines
title_sort	new isoflavanes from <i>spatholobus suberectus</i> and their cytotoxicity against human breast cancer cell lines
publisher	MDPI AG
series	Molecules
issn	1420-3049
publishDate	2019-09-01
description	The rattans of <i>Spatholobus suberectus</i> Dunn are a traditional Chinese medicine activating blood circulation and removing stasis. They have often been used for the traditional Chinese medicinal treatment of breast cancer in modern China. In this study, four novel isoflavanes (<b>1</b>−<b>3</b> and <b>5</b>) and four known analogues (<b>4</b> and <b>6</b>−<b>8</b>) were isolated from an ethanolic extract of the rattans of <i>S. suberectus</i>. Their structures were elucidated by extensive spectroscopic analyses and electronic circular dichroism studies. MCF-7 and MDA-MB-231 human breast cancer cell lines were used to evaluate the cytotoxic effects of the isolates. Interestingly, compounds <b>1</b> and <b>2</b> only inhibited the proliferation of MCF-7 cells, while compound <b>6</b> showed a selective cytotoxicity against MDA-MB-231 cells. However, compound <b>4</b> had significant cytotoxicity against both MCF-7 and MDA-MB-231 cell lines.
topic	<i>Spatholobus suberectus</i> isoflavanes breast cancer MCF-7 MDA-MB-231
url	https://www.mdpi.com/1420-3049/24/18/3218
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New Isoflavanes from <i>Spatholobus suberectus</i> and Their Cytotoxicity against Human Breast Cancer Cell Lines

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