Cortisol Regeneration in the Fetal Membranes, A Coincidental or Requisite Event in Human Parturition?

Cortisol Regeneration in the Fetal Membranes, A Coincidental or Requisite Event in Human Parturition?

The fetal membranes are equipped with high capacity of cortisol regeneration through the reductase activity of 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1). The expression of 11β-HSD1 in the fetal membranes is under the feedforward induction by cortisol, which is potentiated by proinflammatory cyto...

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Bibliographic Details
Main Authors: Wang-Sheng Wang, Chun-Ming Guo, Kang Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Physiology
Subjects:
11β-HSD1
collagen
prostaglandins
glucocorticoids
fetal membranes
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2020.00462/full

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