Subversion of mucosal barrier polarity by Pseudomonas aeruginosa

The lumenal surfaces of human body are lined by a monolayer of epithelia that together with mucus secreting cells and specialized immune cells form the mucosal barrier. This barrier is one of the most fundamental components of the innate immune system, protecting organisms from the vast environmenta...

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Main Authors: Joanne eEngel, Yonatan eEran
Format: Article
Language:English
Published: Frontiers Media S.A. 2011-05-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2011.00114/full
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spelling doaj-afedb128d09a4a48aeae469f799183da2020-11-24T23:02:00ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882011-05-01210.3389/fmicb.2011.0011410074Subversion of mucosal barrier polarity by Pseudomonas aeruginosaJoanne eEngel0Yonatan eEran1University of California, San FranciscoUniversity of California, San FranciscoThe lumenal surfaces of human body are lined by a monolayer of epithelia that together with mucus secreting cells and specialized immune cells form the mucosal barrier. This barrier is one of the most fundamental components of the innate immune system, protecting organisms from the vast environmental microbiota. The mucosal epithelium is comprised of polarized epithelial cells with distinct apical and basolateral surfaces that are defined by unique set of protein and lipid composition and are separated by tight junctions. The apical surface serves as a barrier to the outside world and is specialized for the exchange of materials with the lumen. The basolateral surface is adapted for interaction with other cells and for exchange with the bloodstream. A wide network of proteins and lipids regulates the formation and maintenance of the epithelium polarity. Many human pathogens have evolved virulence mechanisms that target this network and interfere with epithelial polarity to enhance binding to the apical surface, enter into cells, and/or cross the mucosal barrier. This review highlights recent advances in our understanding of how Pseudomonas aeruginosa, an important opportunistic human pathogen that preferentially infects damaged epithelial tissues, exploits the epithelial cell polarization machinery to enhance infection.http://journal.frontiersin.org/Journal/10.3389/fmicb.2011.00114/fullAdherens JunctionsCell PolarityPseudomonas aeruginosaTight JunctionsMicrobial Pathogenesisepithelial barrier
collection DOAJ
language English
format Article
sources DOAJ
author Joanne eEngel
Yonatan eEran
spellingShingle Joanne eEngel
Yonatan eEran
Subversion of mucosal barrier polarity by Pseudomonas aeruginosa
Frontiers in Cellular and Infection Microbiology
Adherens Junctions
Cell Polarity
Pseudomonas aeruginosa
Tight Junctions
Microbial Pathogenesis
epithelial barrier
author_facet Joanne eEngel
Yonatan eEran
author_sort Joanne eEngel
title Subversion of mucosal barrier polarity by Pseudomonas aeruginosa
title_short Subversion of mucosal barrier polarity by Pseudomonas aeruginosa
title_full Subversion of mucosal barrier polarity by Pseudomonas aeruginosa
title_fullStr Subversion of mucosal barrier polarity by Pseudomonas aeruginosa
title_full_unstemmed Subversion of mucosal barrier polarity by Pseudomonas aeruginosa
title_sort subversion of mucosal barrier polarity by pseudomonas aeruginosa
publisher Frontiers Media S.A.
series Frontiers in Cellular and Infection Microbiology
issn 2235-2988
publishDate 2011-05-01
description The lumenal surfaces of human body are lined by a monolayer of epithelia that together with mucus secreting cells and specialized immune cells form the mucosal barrier. This barrier is one of the most fundamental components of the innate immune system, protecting organisms from the vast environmental microbiota. The mucosal epithelium is comprised of polarized epithelial cells with distinct apical and basolateral surfaces that are defined by unique set of protein and lipid composition and are separated by tight junctions. The apical surface serves as a barrier to the outside world and is specialized for the exchange of materials with the lumen. The basolateral surface is adapted for interaction with other cells and for exchange with the bloodstream. A wide network of proteins and lipids regulates the formation and maintenance of the epithelium polarity. Many human pathogens have evolved virulence mechanisms that target this network and interfere with epithelial polarity to enhance binding to the apical surface, enter into cells, and/or cross the mucosal barrier. This review highlights recent advances in our understanding of how Pseudomonas aeruginosa, an important opportunistic human pathogen that preferentially infects damaged epithelial tissues, exploits the epithelial cell polarization machinery to enhance infection.
topic Adherens Junctions
Cell Polarity
Pseudomonas aeruginosa
Tight Junctions
Microbial Pathogenesis
epithelial barrier
url http://journal.frontiersin.org/Journal/10.3389/fmicb.2011.00114/full
work_keys_str_mv AT joanneeengel subversionofmucosalbarrierpolaritybypseudomonasaeruginosa
AT yonataneeran subversionofmucosalbarrierpolaritybypseudomonasaeruginosa
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