Role of DNA recognition receptors in pathogenic mechanism of hepatitis B

Role of DNA recognition receptors in pathogenic mechanism of hepatitis B

As a global disease, hepatitis B still threatens human health. However, the pathogenesis of hepatitis caused by HBV remains unclear. The innate immune system in the liver can detect HBV infection and use every strategy to eliminate the virus. DNA recognition receptors play an important role in this...

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Main Authors: HUANG Jin, PANG Xiuqing, XIE Dongying
Format: Article
Language:zho
Published: Editorial Department of Journal of Clinical Hepatology 2017-09-01
Series:Linchuang Gandanbing Zazhi
Subjects:
hepatitis B; receptors
pattern recognition; review
Online Access:http://www.lcgdbzz.org/qk_content.asp?id=8456
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spelling doaj-afe83cd5571f4a13b3fa5020d375ad412020-11-24T23:28:05ZzhoEditorial Department of Journal of Clinical HepatologyLinchuang Gandanbing Zazhi1001-52561001-52562017-09-013391794179710.3969/j.issn.1001-5256.2017.09.037Role of DNA recognition receptors in pathogenic mechanism of hepatitis BHUANG Jin0PANG Xiuqing1XIE Dongying2Hepatopathy Laboratory, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, ChinaHepatopathy Laboratory, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, ChinaHepatopathy Laboratory, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, ChinaAs a global disease, hepatitis B still threatens human health. However, the pathogenesis of hepatitis caused by HBV remains unclear. The innate immune system in the liver can detect HBV infection and use every strategy to eliminate the virus. DNA recognition receptors play an important role in this process; they recognize HBV DNA or pgRNA in cytoplasm or nucleus, activate innate immunity through various signaling pathways to produce inflammatory cytokines and interferon, and finally exert their antiviral effect. This article summarizes the DNA recognition receptors involved in inflammation induced by HBV and HBV clearance, elaborates on their detailed pathways, and discusses the issues regarding the role of DNA recognition receptors in liver innate immunity induced by HBV and related perspectives. http://www.lcgdbzz.org/qk_content.asp?id=8456hepatitis B; receptorspattern recognition; review
collection DOAJ
language zho
format Article
sources DOAJ
author HUANG Jin
PANG Xiuqing
XIE Dongying
spellingShingle HUANG Jin
PANG Xiuqing
XIE Dongying
Role of DNA recognition receptors in pathogenic mechanism of hepatitis B
Linchuang Gandanbing Zazhi
hepatitis B; receptors
pattern recognition; review
author_facet HUANG Jin
PANG Xiuqing
XIE Dongying
author_sort HUANG Jin
title Role of DNA recognition receptors in pathogenic mechanism of hepatitis B
title_short Role of DNA recognition receptors in pathogenic mechanism of hepatitis B
title_full Role of DNA recognition receptors in pathogenic mechanism of hepatitis B
title_fullStr Role of DNA recognition receptors in pathogenic mechanism of hepatitis B
title_full_unstemmed Role of DNA recognition receptors in pathogenic mechanism of hepatitis B
title_sort role of dna recognition receptors in pathogenic mechanism of hepatitis b
publisher Editorial Department of Journal of Clinical Hepatology
series Linchuang Gandanbing Zazhi
issn 1001-5256
1001-5256
publishDate 2017-09-01
description As a global disease, hepatitis B still threatens human health. However, the pathogenesis of hepatitis caused by HBV remains unclear. The innate immune system in the liver can detect HBV infection and use every strategy to eliminate the virus. DNA recognition receptors play an important role in this process; they recognize HBV DNA or pgRNA in cytoplasm or nucleus, activate innate immunity through various signaling pathways to produce inflammatory cytokines and interferon, and finally exert their antiviral effect. This article summarizes the DNA recognition receptors involved in inflammation induced by HBV and HBV clearance, elaborates on their detailed pathways, and discusses the issues regarding the role of DNA recognition receptors in liver innate immunity induced by HBV and related perspectives.
topic hepatitis B; receptors
pattern recognition; review
url http://www.lcgdbzz.org/qk_content.asp?id=8456
work_keys_str_mv AT huangjin roleofdnarecognitionreceptorsinpathogenicmechanismofhepatitisb
AT pangxiuqing roleofdnarecognitionreceptorsinpathogenicmechanismofhepatitisb
AT xiedongying roleofdnarecognitionreceptorsinpathogenicmechanismofhepatitisb
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