HIF-1-miR-219-SMC4 Regulatory Pathway Promoting Proliferation and Migration of HCC under Hypoxic Condition

HIF-1-miR-219-SMC4 Regulatory Pathway Promoting Proliferation and Migration of HCC under Hypoxic Condition

This paper aims to investigate the function of structural maintenance of chromosome 4 (SMC4) in the progression of hepatocellular carcinoma (HCC) under hypoxic condition. In this study, we found that suppression of SMC4 could inhibit proliferation and migration of HCC cells through inducing G1 phase...

Full description

Bibliographic Details
Main Authors:	Yang Chen, Fei Huang, liang Deng, Xiaowei Yuan, Qiang Tao, Tielong Wang, Dong Li, Youwen Fan, Quanzhou Peng, Di Tang
Format:	Article
Language:	English
Published:	Hindawi Limited 2019-01-01
Series:	BioMed Research International
Online Access:	http://dx.doi.org/10.1155/2019/8983704

Similar Items

Correction to: A novel miR-219-SMC4-JAK2/Stat3 regulatory pathway in human hepatocellular carcinoma
by: Bo Zhou, et al.
Published: (2021-07-01)

MiR-150 regulates human keratinocyte proliferation in hypoxic conditions through targeting HIF-1α and VEGFA: Implications for psoriasis treatment.
by: Yongjian Li, et al.
Published: (2017-01-01)

MiR-141 suppresses the migration and invasion of HCC cells by targeting Tiam1.
by: Ying Liu, et al.
Published: (2014-01-01)

Gga-miR-219b targeting BCL11B suppresses proliferation, migration and invasion of Marek’s disease tumor cell MSB1
by: Chunfang Zhao, et al.
Published: (2017-06-01)

MiR-219-5p suppresses cell proliferation and cell cycle progression in esophageal squamous cell carcinoma by targeting CCNA2
by: Qiang Ma
Published: (2019-02-01)

LncRNA SNHG11 Promotes Proliferation, Migration, Apoptosis, and Autophagy by Regulating hsa-miR-184/AGO2 in HCC
by: Huang W, et al.
Published: (2020-01-01)

Emerging Roles Of hsa-circ-0046600 Targeting The miR-640/HIF-1α Signalling Pathway In The Progression Of HCC
by: Zhai Z, et al.
Published: (2019-11-01)

Transcriptional regulation of hsa-miR-122 in HCC
by: Pei-Yun Chiang Heish, et al.
Published: (2009)

hsa_circ_0001955 Enhances In Vitro Proliferation, Migration, and Invasion of HCC Cells through miR-145-5p/NRAS Axis
by: Bisha Ding, et al.
Published: (2020-12-01)

XPD suppresses cell proliferation and migration via miR-29a-3p-Mdm2/PDGF-B axis in HCC
by: Zhihua Xiao, et al.
Published: (2019-01-01)

The TLX-miR-219 cascade regulates neural stem cell proliferation in neurodevelopment and schizophrenia iPSC model
by: Kiyohito Murai, et al.
Published: (2016-03-01)

Effects of miR-219/miR-338 on microglia and astrocyte behaviors and astrocyte-oligodendrocyte precursor cell interactions
by: Lan Huong Nguyen, et al.
Published: (2020-01-01)

Regulator of oligodendrocyte maturation, miR-219, a potential biomarker for MS
by: Ilona B. Bruinsma, et al.
Published: (2017-12-01)

Predictive Value of MiR-219-1, MiR-938, MiR-34b/c, and MiR-218 Polymorphisms for Gastric Cancer Susceptibility and Prognosis
by: Yanhua Wu, et al.
Published: (2017-01-01)

miR-31 Ablates Expression of the HIF Regulatory Factor FIH to Activate the HIF Pathway in Oral Squamous Cell Carcinoma
by: Meng-Miao Tsai, et al.
Published: (2011)

Hsa-miR122 regulates intrahepatic metastasis of HCC
by: Wei-Chih Tsai, et al.
Published: (2008)

MiR-935/HIF1α Feedback Loop Inhibits the Proliferation and Invasiveness of Glioma
by: Huang G, et al.
Published: (2020-10-01)

Circulating microRNAs, miR-939, miR-595, miR-519d and miR-494, Identify Cirrhotic Patients with HCC.
by: Francesca Fornari, et al.
Published: (2015-01-01)

HIF-1α had Pivotal Effects on Downregulation of miR-210 Decreasing Viability and Inducing Apoptosis in Hypoxic Chondrocytes
by: Zhiqiang Chang, et al.
Published: (2014-01-01)

Overexpressing lncRNA SNHG16 inhibited HCC proliferation and chemoresistance by functionally sponging hsa-miR-93
by: Xu F, et al.
Published: (2018-12-01)

Epigenetically modulated miR-1224 suppresses the proliferation of HCC through CREB-mediated activation of YAP signaling pathway
by: Shikun Yang, et al.
Published: (2021-03-01)

miR-103/miR-195/miR-15b Regulate SALL4 and Inhibit Proliferation and Migration in Glioma
by: Li-Ping Chen, et al.
Published: (2018-11-01)

Circ_0072995 Promotes Proliferation and Invasion via Regulating miR-1253/EIF4A3 Signaling in HCC
by: He Q, et al.
Published: (2021-08-01)

Phosphorylation of the PDH complex precedes HIF-1-mediated effects and PDK1 upregulation during the first hours of hypoxic treatment in HCC cells
by: Zimmer AD, et al.
Published: (2016-08-01)

MiR-200c downregulates HIF-1α and inhibits migration of lung cancer cells
by: Yuree Byun, et al.
Published: (2019-04-01)

Characterization of oncomiRs in HCC: Implication of miR-122 in metastatic tumor
by: Ching-Wen Lin, et al.
Published: (2006)

Investigate the factors involved in miR-18a elevation in female HCC
by: Chiao-Ling Li, et al.
Published: (2010)

Effects of miR-99a on the migration and proliferation of glioma cells
by: Xu Yifan, et al.
Published: (2018-04-01)

Expressão dos microRNAs miR-15, miR-29, miR219 e miR-222 em ratos submetidos a isquemia cerebral focal associada ao exercício físico
by: Cirino, Mucio Luiz de Assis
Published: (2018)

miR-219-5p inhibits receptor tyrosine kinase pathway by targeting EGFR in glioblastoma.
by: Soumya Alige Mahabala Rao, et al.
Published: (2013-01-01)

Hypothalamic miR-219 regulates individual metabolic differences in response to diet-induced weight cycling
by: Mariana Schroeder, et al.
Published: (2018-03-01)

MiR-219-5p Inhibits the Growth and Metastasis of Malignant Melanoma by Targeting BCL-2
by: Jianwen Long, et al.
Published: (2017-01-01)

Regulatory Effects of microRNA-92 (miR-92) on VHL Gene Expression and the Hypoxic Activation of miR-210 in Clear Cell Renal Cell Carcinoma
by: Vladimir A. Valera, Beatriz A. Walter, W. Marston Linehan, Maria J. Merino
Published: (2011-01-01)

Novel miRNA, miR-sc14, promotes Schwann cell proliferation and migration
by: Xi-Meng Ji, et al.
Published: (2019-01-01)

Arresting the Culprit: Targeted Antagomir Delivery to Sequester Oncogenic miR-221 in HCC
by: Andrea L Kasinski, et al.
Published: (2012-01-01)

Circ-ZEB1.33 promotes the proliferation of human HCC by sponging miR-200a-3p and upregulating CDK6
by: Yuhua Gong, et al.
Published: (2018-08-01)

The miR-497 promotes proliferation and migration in MHCC97L cells
by: Wei-Sheng Hu, et al.
Published: (2020-03-01)

Nerve Growth Factor Neutralization Promotes Oligodendrogenesis by Increasing miR-219a-5p Levels
by: Rossella Brandi, et al.
Published: (2021-02-01)

MiR-219-5p inhibits growth and metastasis of ovarian cancer cells by targeting HMGA2
by: Feng Xing, et al.
Published: (2018-11-01)

The CREB-miR-9 negative feedback minicircuitry coordinates the migration and proliferation of glioma cells.
by: Xiaochao Tan, et al.
Published: (2012-01-01)

Cannot write session to /tmp/vufind_sessions/sess_mi403sc0dthmretj7s0epdiptr