The effects of exendin-4 treatment on graft failure: an animal study using a novel re-vascularized minimal human islet transplant model.

The effects of exendin-4 treatment on graft failure: an animal study using a novel re-vascularized minimal human islet transplant model.

Islet transplantation has become a viable clinical treatment, but is still compromised by long-term graft failure. Exendin-4, a glucagon-like peptide 1 receptor agonist, has in clinical studies been shown to improve insulin secretion in islet transplanted patients. However, little is known about the...

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Main Authors: Afaf Sahraoui, Maria Sörhede Winzell, Tracy Gorman, Dave M Smith, Stanko Skrtic, Merete Hoeyem, Shadab Abadpour, Lars Johansson, Olle Korsgren, Aksel Foss, Hanne Scholz
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4368803?pdf=render

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