Blockade of the Adenosine A<sub>3</sub> Receptor Attenuates Caspase 1 Activation in Renal Tubule Epithelial Cells and Decreases Interleukins IL-1β and IL-18 in Diabetic Rats

Blockade of the Adenosine A<sub>3</sub> Receptor Attenuates Caspase 1 Activation in Renal Tubule Epithelial Cells and Decreases Interleukins IL-1β and IL-18 in Diabetic Rats

Diabetic nephropathy (DN) is the main cause of end-stage renal disease, which remains incurable. The progression of DN is associated with progressive and irreversible renal fibrosis and also high levels of adenosine. Our aim was to evaluate the effects of ADORA3 antagonism on renal injury in strepto...

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Bibliographic Details
Main Authors: Wallys Garrido, Claudia Jara, Angelo Torres, Raibel Suarez, Claudio Cappelli, Carlos Oyarzún, Claudia Quezada, Rody San Martín
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:International Journal of Molecular Sciences
Subjects:
adenosine receptor
diabetic nephropathy
interleukins 1 and 18
renal fibrosis
inflammasome
Online Access:https://www.mdpi.com/1422-0067/20/18/4531

Internet

https://www.mdpi.com/1422-0067/20/18/4531

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