Serum Zinc and Magnesium Levels in Children with Febrile Seizure: A Hospital Based Cross-Sectional Study
Introduction: Febrile Seizure (FS) is one of the most common forms of seizures in children. Precise aetiology of FS is still not known. Studies have shown that micronutrients like zinc, magnesium, iron, selenium, and copper are highly effective in preventing FS. Aim: To assess serum zinc and ma...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Pvt. Ltd.
2021-04-01
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| Series: | National Journal of Laboratory Medicine |
| Subjects: | |
| Online Access: | http://www.njlm.net/articles/PDF/2457/44706_CE[Ra1]_F(SHU)_PF1(ShG_SHU)_PFA(SHU_ShG)_PN(SHU).pdf |
| Summary: | Introduction: Febrile Seizure (FS) is one of the most common
forms of seizures in children. Precise aetiology of FS is still
not known. Studies have shown that micronutrients like zinc,
magnesium, iron, selenium, and copper are highly effective in
preventing FS.
Aim: To assess serum zinc and magnesium levels in children
with FS and to compare them with that of febrile children without
seizure, in order to find out whether serum zinc and magnesium
levels have any relationship with occurrence of FS.
Materials and Methods: This was a hospital based comparative
cross-sectional study done in the Paediatrics department of
Assam Medical College, Dibrugarh, Assam (India). One hundred
and thirty children between 6-60 months, with first episode of
FS, admitted in the department of paediatrics from June 2016
to May 2017 were taken as cases and 130 age and sex matched
febrile children without seizure were taken as controls. After
recording history, examination findings and investigations on
pre-designed proforma, serum zinc and magnesium levels were
estimated using colorimetric and modified methylthymol blue
method respectively and comparison was made between cases
and controls, and also among simple and complex FS. Data
were analysed by Microsoft Excel 2010 and SPSS (Statistical
Package for the Social Sciences) program version 16.0 and
p<0.05 was taken as significant.
Results: Mean serum zinc levels in cases and controls were
(79.68±21.7 μg/dL) and (120.93±29.00 μg/dL), respectively.
Hypozincaemia was present in 14 (10.77%) cases and 1
(0.77%) control (p<0.001). Mean serum magnesium levels in
cases and controls were 2.02±0.21 mg/dL) and (2.22±0.22
mg/dL), respectively. Hypomagnesemia was present in 8
(6.15%) cases while none of the controls had hypomagnesemia
(p=0.006). Mean serum zinc levels in cases with simple and
complex FS were (85.55±24.13 μg/dL) and (71.92±14.97 μg/
dL), respectively (p<0.001). Mean serum magnesium levels in
simple and complex FS were (2.11±0.21 mg/dL) and (1.90±0.14
mg/dL), respectively (p<0.001).
Conclusion: Children with FS had low serum zinc and
magnesium levels in comparison to febrile children without
seizure and both the levels were lower in children with complex |
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| ISSN: | 2277-8551 2455-6882 |