A tool for discovering drug sensitivity and gene expression associations in cancer cells.

A tool for discovering drug sensitivity and gene expression associations in cancer cells.

The sensitivity of cancer cells to anticancer drugs is a crucial factor for developing effective treatments. However, it is still challenging to precisely predict the effectiveness of therapeutics in humans within a complex genomic and molecular context. We developed an interface which allows the us...

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Bibliographic Details
Main Authors: Yong Qin, Anthony P Conley, Elizabeth A Grimm, Jason Roszik
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5409143?pdf=render
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spelling doaj-af98f1e7329745338dfc286ecd87ccec2020-11-25T02:47:26ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01124e017676310.1371/journal.pone.0176763A tool for discovering drug sensitivity and gene expression associations in cancer cells.Yong QinAnthony P ConleyElizabeth A GrimmJason RoszikThe sensitivity of cancer cells to anticancer drugs is a crucial factor for developing effective treatments. However, it is still challenging to precisely predict the effectiveness of therapeutics in humans within a complex genomic and molecular context. We developed an interface which allows the user to rapidly explore drug sensitivity and gene expression associations. Predictions for how expression of various genes affect anticancer drug activity are available for all genes for a set of therapeutics based on data from various cell lines of different origin in the Cancer Cell Line Encyclopedia and the Genomics of Drug Sensitivity in Cancer projects. Our application makes discovery or validation of drug sensitivity and gene expression associations efficient. Effectiveness of this tool is demonstrated by multiple known and novel examples.http://europepmc.org/articles/PMC5409143?pdf=render
collection DOAJ
language English
format Article
sources DOAJ
author Yong Qin
Anthony P Conley
Elizabeth A Grimm
Jason Roszik
spellingShingle Yong Qin
Anthony P Conley
Elizabeth A Grimm
Jason Roszik
A tool for discovering drug sensitivity and gene expression associations in cancer cells.
PLoS ONE
author_facet Yong Qin
Anthony P Conley
Elizabeth A Grimm
Jason Roszik
author_sort Yong Qin
title A tool for discovering drug sensitivity and gene expression associations in cancer cells.
title_short A tool for discovering drug sensitivity and gene expression associations in cancer cells.
title_full A tool for discovering drug sensitivity and gene expression associations in cancer cells.
title_fullStr A tool for discovering drug sensitivity and gene expression associations in cancer cells.
title_full_unstemmed A tool for discovering drug sensitivity and gene expression associations in cancer cells.
title_sort tool for discovering drug sensitivity and gene expression associations in cancer cells.
publisher Public Library of Science (PLoS)
series PLoS ONE
issn 1932-6203
publishDate 2017-01-01
description The sensitivity of cancer cells to anticancer drugs is a crucial factor for developing effective treatments. However, it is still challenging to precisely predict the effectiveness of therapeutics in humans within a complex genomic and molecular context. We developed an interface which allows the user to rapidly explore drug sensitivity and gene expression associations. Predictions for how expression of various genes affect anticancer drug activity are available for all genes for a set of therapeutics based on data from various cell lines of different origin in the Cancer Cell Line Encyclopedia and the Genomics of Drug Sensitivity in Cancer projects. Our application makes discovery or validation of drug sensitivity and gene expression associations efficient. Effectiveness of this tool is demonstrated by multiple known and novel examples.
url http://europepmc.org/articles/PMC5409143?pdf=render
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AT elizabethagrimm atoolfordiscoveringdrugsensitivityandgeneexpressionassociationsincancercells
AT jasonroszik atoolfordiscoveringdrugsensitivityandgeneexpressionassociationsincancercells
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AT anthonypconley toolfordiscoveringdrugsensitivityandgeneexpressionassociationsincancercells
AT elizabethagrimm toolfordiscoveringdrugsensitivityandgeneexpressionassociationsincancercells
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