Interaction of clinical-stage antibodies with heme predicts their physiochemical and binding qualities

Interaction of clinical-stage antibodies with heme predicts their physiochemical and binding qualities

Lecerf et al. examine over 100 samples with variable region sequences matching clinical-stage immunoglobulin antibodies, to demonstrate that many interact with heme. They find that those that do interact with heme possess specific sequence traits that manifest qualities such as increased hydrophobic...

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Main Authors: Maxime Lecerf, Alexia Kanyavuz, Sofia Rossini, Jordan D. Dimitrov
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-021-01931-7
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spelling doaj-af921751134f450894b0f294ada57a9b2021-03-28T11:24:21ZengNature Publishing GroupCommunications Biology2399-36422021-03-014111310.1038/s42003-021-01931-7Interaction of clinical-stage antibodies with heme predicts their physiochemical and binding qualitiesMaxime Lecerf0Alexia Kanyavuz1Sofia Rossini2Jordan D. Dimitrov3Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université de ParisCentre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université de ParisCentre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université de ParisCentre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université de ParisLecerf et al. examine over 100 samples with variable region sequences matching clinical-stage immunoglobulin antibodies, to demonstrate that many interact with heme. They find that those that do interact with heme possess specific sequence traits that manifest qualities such as increased hydrophobicity, self-binding and intrinsic polyreactivity, thus suggesting that heme interaction is a predictor for therapeutically important qualities.https://doi.org/10.1038/s42003-021-01931-7
collection DOAJ
language English
format Article
sources DOAJ
author Maxime Lecerf
Alexia Kanyavuz
Sofia Rossini
Jordan D. Dimitrov
spellingShingle Maxime Lecerf
Alexia Kanyavuz
Sofia Rossini
Jordan D. Dimitrov
Interaction of clinical-stage antibodies with heme predicts their physiochemical and binding qualities
Communications Biology
author_facet Maxime Lecerf
Alexia Kanyavuz
Sofia Rossini
Jordan D. Dimitrov
author_sort Maxime Lecerf
title Interaction of clinical-stage antibodies with heme predicts their physiochemical and binding qualities
title_short Interaction of clinical-stage antibodies with heme predicts their physiochemical and binding qualities
title_full Interaction of clinical-stage antibodies with heme predicts their physiochemical and binding qualities
title_fullStr Interaction of clinical-stage antibodies with heme predicts their physiochemical and binding qualities
title_full_unstemmed Interaction of clinical-stage antibodies with heme predicts their physiochemical and binding qualities
title_sort interaction of clinical-stage antibodies with heme predicts their physiochemical and binding qualities
publisher Nature Publishing Group
series Communications Biology
issn 2399-3642
publishDate 2021-03-01
description Lecerf et al. examine over 100 samples with variable region sequences matching clinical-stage immunoglobulin antibodies, to demonstrate that many interact with heme. They find that those that do interact with heme possess specific sequence traits that manifest qualities such as increased hydrophobicity, self-binding and intrinsic polyreactivity, thus suggesting that heme interaction is a predictor for therapeutically important qualities.
url https://doi.org/10.1038/s42003-021-01931-7
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AT alexiakanyavuz interactionofclinicalstageantibodieswithhemepredictstheirphysiochemicalandbindingqualities
AT sofiarossini interactionofclinicalstageantibodieswithhemepredictstheirphysiochemicalandbindingqualities
AT jordanddimitrov interactionofclinicalstageantibodieswithhemepredictstheirphysiochemicalandbindingqualities
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