Attempted Synthesis of Vinca Alkaloids Condensed with Three-Membered Rings

Attempted Synthesis of Vinca Alkaloids Condensed with Three-Membered Rings

Our successful work for the synthesis of cyclopropanated vinblastine and its derivatives by the Simmons–Smith reaction was followed to build up further three-membered rings into the 14,15-position of the vindoline part of the dimer alkaloid. Halogenated 14,15-cyclopropanovindoline was prep...

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Bibliographic Details
Main Authors: András Keglevich, Szabolcs Mayer, Réka Pápai, Áron Szigetvári, Zsuzsanna Sánta, Miklós Dékány, Csaba Szántay, Péter Keglevich, László Hazai
Format: Article
Language:English
Published: MDPI AG 2018-10-01
Series:Molecules
Subjects:
halogencyclopropane
dichlorocarbene
epoxidation
vindoline
catharanthine
dimer alkaloids
vindoline trimer
Online Access:http://www.mdpi.com/1420-3049/23/10/2574

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