Diverging mRNA and Protein Networks in Activated Microglia Reveal SRSF3 Suppresses Translation of Highly Upregulated Innate Immune Transcripts

Diverging mRNA and Protein Networks in Activated Microglia Reveal SRSF3 Suppresses Translation of Highly Upregulated Innate Immune Transcripts

Uncontrolled microglial activation may lead to the development of inflammation-induced brain damage. Here, we uncover a ribosome-based mechanism/checkpoint involved in control of the innate immune response and microglial activation. Using an in vivo model system for analysis of the dynamic translati...

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Bibliographic Details
Main Authors: Hejer Boutej, Reza Rahimian, Sai Sampath Thammisetty, Louis-Charles Béland, Mélanie Lalancette-Hébert, Jasna Kriz
Format: Article
Language:English
Published: Elsevier 2017-12-01
Series:Cell Reports
Subjects:
microglia
innate immune response
translatome profiling
microglia proteomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717317102

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http://www.sciencedirect.com/science/article/pii/S2211124717317102

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