Synthesis, characterization, antimicrobial screening and cytotoxic properties of Cu(II) and Zn(II) complexes with bidentate hydroxylated 1,3-diaryl-2-propene-1-ones ligand

• Main Authors: Patil Pravinkumar, Zangade Sainath
• Format: Article
• Language: English
• Published: Serbian Chemical Society 2021-01-01
• Series: Journal of the Serbian Chemical Society
• Subjects: metal complexes; 1,3-diaryl-2-propene-1-one derivatives; antimicrobial activity; cytotoxicity; anticancer activity
• Online Access: http://www.doiserbia.nb.rs/img/doi/0352-5139/2021/0352-51392000068P.pdf
• ISSN: 0352-5139; 1820-7421

A series of binary metal complexes (halo, hydroxyl and methoxy substituted bis(2-(E)acryloyl)naphthalen-1-yl)oxy)Cu(II) and Zn(II) (C1– –C10)) of Cu2+ and Zn2+ ions derived from bi-coordinated hydroxylated 1,3- -diaryl-2-propene-1-ones were synthesized. The newly synthesized metal complexes were structurally determined by FT-IR, 1H-NMR, 13C-NMR, ESR spectral, XRD and TGA analyses. The FT-IR and ESR studies demonstrated that interactions between metal ions with ligands occur through carbonyl oxygen and deprotonated hydroxyl oxygen and correspond to square-planar geometry for all complexes. The metal complexes were screened in-vitro and evaluated for their antimicrobial and cytotoxic activities. The complexes C1 and C4 showed significant antimicrobial activity while the remaining complexes showed moderate antimicrobial activity against the tested pathogens. The complexes were evaluated for cytotoxic activity against the organism Artemia salina. Complexes C2–C5 exhibited LC50 values of 630.45, 969.99, 921.94 and 918.41 μM mL-1, respectively. Furthermore, the complexes were evaluated for their anticancer activity against the liver cancer cell line Hep G2 in comparison with the 5-fluorouracil standard. Complex C5 showed a significant IC50 value of 58.94 μg mL-1. Therefore, the present study is useful for the development of a new class of antimicrobial and anticancer agents.