Notch Signaling Rescues Loss of Satellite Cells Lacking Pax7 and Promotes Brown Adipogenic Differentiation

Notch Signaling Rescues Loss of Satellite Cells Lacking Pax7 and Promotes Brown Adipogenic Differentiation

Pax7 is a nodal transcription factor that is essential for regulating the maintenance, expansion, and myogenic identity of satellite cells during both neonatal and adult myogenesis. Deletion of Pax7 results in loss of satellite cells and impaired muscle regeneration. Here, we show that ectopic expre...

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Bibliographic Details
Main Authors: Alessandra Pasut, Natasha C. Chang, Uxia Gurriaran Rodriguez, Sharlene Faulkes, Hang Yin, Melanie Lacaria, Hong Ming, Michael A. Rudnicki
Format: Article
Language:English
Published: Elsevier 2016-07-01
Series:Cell Reports
Subjects:
Pax7
Notch1
NICD1
satellite cells
myogenic
brown adipogenic
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716307203

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http://www.sciencedirect.com/science/article/pii/S2211124716307203

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