BRAF p.V600E associated poly-neoplastic syndrome

We report a male patient who developed eight different cancers between ages 57 and 64. BRAF p.V600E mutation was detected in Langerhans cell histiocytosis, chronic lymphocytic leukemia, histiocytic sarcoma, melanoma, and adenocarcinoma of the lung. It was not detected in multiple myeloma, basal cell...

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Main Authors:	Muhamad Alhaj Moustafa, Liuyan Jiang, Justin J Kuhlman, Jeremy Jones, Yanyan Lou, Olayemi Sokumbi, Han W Tun
Format:	Article
Language:	English
Published:	SAGE Publishing 2021-04-01
Series:	Rare Tumors
Online Access:	https://doi.org/10.1177/20363613211012929

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spelling	doaj-af7c484c18704093beb3b602d55301132021-05-08T21:33:36ZengSAGE PublishingRare Tumors2036-36132021-04-011310.1177/20363613211012929BRAF p.V600E associated poly-neoplastic syndromeMuhamad Alhaj Moustafa0Liuyan Jiang1Justin J Kuhlman2Jeremy Jones3Yanyan Lou4Olayemi Sokumbi5Han W Tun6Division of Hematology and Medical Oncology, Mayo Clinic Florida, Jacksonville, FL, USADepartment of Pathology, Mayo Clinic Florida, Jacksonville, FL, USADepartment of Internal Medicine, Mayo Clinic Florida, Jacksonville, FL, USADivision of Hematology and Medical Oncology, Mayo Clinic Florida, Jacksonville, FL, USADivision of Hematology and Medical Oncology, Mayo Clinic Florida, Jacksonville, FL, USADepartment of Dermatology, Mayo Clinic Florida, Jacksonville, FL, USADivision of Hematology and Medical Oncology, Mayo Clinic Florida, Jacksonville, FL, USAWe report a male patient who developed eight different cancers between ages 57 and 64. BRAF p.V600E mutation was detected in Langerhans cell histiocytosis, chronic lymphocytic leukemia, histiocytic sarcoma, melanoma, and adenocarcinoma of the lung. It was not detected in multiple myeloma, basal cell carcinoma, and papillary thyroid cancer. BRAF p.V600E was not detected in normal skin tissue biopsy indicating that BRAF V600E was a somatic mutation affecting cancer cells. The presence of eight different cancers with five of them positive for BRAF p.V600E in a single patient is unprecedented. This type of BRAF p.V600E-associated poly-neoplastic syndrome has never been reported in the medical literature.https://doi.org/10.1177/20363613211012929
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Muhamad Alhaj Moustafa Liuyan Jiang Justin J Kuhlman Jeremy Jones Yanyan Lou Olayemi Sokumbi Han W Tun
spellingShingle	Muhamad Alhaj Moustafa Liuyan Jiang Justin J Kuhlman Jeremy Jones Yanyan Lou Olayemi Sokumbi Han W Tun BRAF p.V600E associated poly-neoplastic syndrome Rare Tumors
author_facet	Muhamad Alhaj Moustafa Liuyan Jiang Justin J Kuhlman Jeremy Jones Yanyan Lou Olayemi Sokumbi Han W Tun
author_sort	Muhamad Alhaj Moustafa
title	BRAF p.V600E associated poly-neoplastic syndrome
title_short	BRAF p.V600E associated poly-neoplastic syndrome
title_full	BRAF p.V600E associated poly-neoplastic syndrome
title_fullStr	BRAF p.V600E associated poly-neoplastic syndrome
title_full_unstemmed	BRAF p.V600E associated poly-neoplastic syndrome
title_sort	braf p.v600e associated poly-neoplastic syndrome
publisher	SAGE Publishing
series	Rare Tumors
issn	2036-3613
publishDate	2021-04-01
description	We report a male patient who developed eight different cancers between ages 57 and 64. BRAF p.V600E mutation was detected in Langerhans cell histiocytosis, chronic lymphocytic leukemia, histiocytic sarcoma, melanoma, and adenocarcinoma of the lung. It was not detected in multiple myeloma, basal cell carcinoma, and papillary thyroid cancer. BRAF p.V600E was not detected in normal skin tissue biopsy indicating that BRAF V600E was a somatic mutation affecting cancer cells. The presence of eight different cancers with five of them positive for BRAF p.V600E in a single patient is unprecedented. This type of BRAF p.V600E-associated poly-neoplastic syndrome has never been reported in the medical literature.
url	https://doi.org/10.1177/20363613211012929
work_keys_str_mv	AT muhamadalhajmoustafa brafpv600eassociatedpolyneoplasticsyndrome AT liuyanjiang brafpv600eassociatedpolyneoplasticsyndrome AT justinjkuhlman brafpv600eassociatedpolyneoplasticsyndrome AT jeremyjones brafpv600eassociatedpolyneoplasticsyndrome AT yanyanlou brafpv600eassociatedpolyneoplasticsyndrome AT olayemisokumbi brafpv600eassociatedpolyneoplasticsyndrome AT hanwtun brafpv600eassociatedpolyneoplasticsyndrome
_version_	1721454956960022528

BRAF p.V600E associated poly-neoplastic syndrome

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