Thy-1 (CD90) Signaling Preferentially Promotes RORγt Expression and a Th17 Response

Thy-1 (CD90) Signaling Preferentially Promotes RORγt Expression and a Th17 Response

Thy-1 (CD90) is a glycosylphosphatidylinositol-anchored protein (GPI-AP) with signaling properties that is abundant on mouse T cells. Upon antibody-mediated crosslinking, Thy-1 provides a T cell receptor (TcR)-like signal that is sufficient to drive CD4+ T cell proliferation and differentiation into...

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Bibliographic Details
Main Authors: Suzanne Furlong, Melanie R. Power Coombs, Javad Ghassemi-Rad, David W. Hoskin
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
CD90
cytokine synthesis
glycosylphosphatidylinositol-anchored protein
T cell
Thy-1
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2018.00158/full

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