Lysosomal Membrane Permeabilization is an Early Event in Sigma-2 Receptor Ligand Mediated Cell Death in Pancreatic Cancer

Lysosomal Membrane Permeabilization is an Early Event in Sigma-2 Receptor Ligand Mediated Cell Death in Pancreatic Cancer

<p>Abstract</p> <p>Background</p> <p>Sigma-2 receptor ligands have been studied for treatment of pancreatic cancer because they are preferentially internalized by proliferating cells and induce apoptosis. This mechanism of apoptosis is poorly understood, with varying re...

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Bibliographic Details
Main Authors: Hornick John R, Vangveravong Suwanna, Spitzer Dirk, Abate Carmen, Berardi Francesco, Goedegebuure Peter, Mach Robert H, Hawkins William G
Format: Article
Language:English
Published: BMC 2012-05-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
sigma-2 receptor
pancreatic cancer
caspase-3
lysosomal membrane permeablization
Online Access:http://www.jeccr.com/content/31/1/41

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