Impact of matrix metalloproteinase 9 rs3918242 genetic variant on lipid-lowering efficacy of simvastatin therapy in Chinese patients with coronary heart disease

Impact of matrix metalloproteinase 9 rs3918242 genetic variant on lipid-lowering efficacy of simvastatin therapy in Chinese patients with coronary heart disease

Abstract Background Genetic variation of matrix metalloproteinase 9 (MMP-9) gene polymorphism has been suggested to modulate coronary heart diseases (CHD), yet the underlying mechanisms are not well understood. Methods We investigated the association of MMP9 rs3918242 single nucleotide polymorphism...

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Bibliographic Details
Main Authors: Yuanyuan Xu, Yan Wang, Jixin Zhi, Lichun Qi, Tong Zhang, Xueqi Li
Format: Article
Language:English
Published: BMC 2017-04-01
Series:BMC Pharmacology and Toxicology
Subjects:
HMG-CoA reductase inhibitor
Genetic polymorphism
MMP9
Coronary heart disease
Online Access:http://link.springer.com/article/10.1186/s40360-017-0132-y

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