NT-proBNP correlates with the illness scores pneumonia severity index and CURB-65 in patients with pneumonia

• Main Authors: Dario Martolini, Eleonora Pistella, Enrico Carmenini, Claudio Santini
• Format: Article
• Language: English
• Published: PAGEPress Publications 2017-03-01
• Series: Italian Journal of Medicine
• Subjects: Pneumonia; NT-proBNP; pneumonia severity index; CURB-65; illness score.
• Online Access: http://www.italjmed.org/index.php/ijm/article/view/728

<em>Pneumonia severity index</em> (PSI) and CURB-65 (<em>confusion, urea, respiratory rate, blood pressure, age ≥65</em>) are used to estimate the severity and prognosis of patients with pneumonia. NT-proBNP is a marker of myocardial stress and of sepsis-induced myocardial depression and might be used to predict short and long-term survival in patients with pneumonia. Twenty-three patients [age 79±15 standard deviation (SD); M/F 8/15, CURB-65 2.2±0.9 SD, PSI 118±38 SD, procalcitonin 3.9±5 SD] with pneumonia hospitalized in our Internal Medicine Unit were retrospectively evaluated. NT-proBNP was measured in the first 72 h of hospitalization. CURB-65 and PSI were calculated and correlation with biomarkers investigated. NT-proBNP showed a moderate statistically significant correlation with both PSI and CURB-65 (NT-proBNP <em>vs</em> PSI, r=0.42, P&lt;0.05, NT-proBNP <em>vs</em> CURB-65, r=0.46, P&lt;0.05). These correlations were confirmed also when patients with a diagnosis of heart failure where excluded from the analysis, even if the correlation did not reach the statistical significance. NT-proBNP seems to well correlate with the illness scores PSI and CURB-65 and might be a reliable predictor of severity and survival in patients with pneumonia.