TGF‐β transactivates EGFR and facilitates breast cancer migration and invasion through canonical Smad3 and ERK/Sp1 signaling pathways

TGF‐β transactivates EGFR and facilitates breast cancer migration and invasion through canonical Smad3 and ERK/Sp1 signaling pathways

Transforming growth factor‐beta (TGF‐β) functions as a potent proliferation inhibitor and apoptosis inducer in the early stages of breast cancer, yet promotes cancer aggressiveness in the advanced stages. The dual effect of TGF‐β on cancer development is known as TGF‐β paradox, and the remarkable fu...

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Bibliographic Details
Main Authors: Yuanyuan Zhao, Jing Ma, Yanling Fan, Zhiyong Wang, Ran Tian, Wei Ji, Fei Zhang, Ruifang Niu
Format: Article
Language:English
Published: Wiley 2018-03-01
Series:Molecular Oncology
Subjects:
breast cancer
EGF receptor
invasion
Smad3
Sp1
transforming growth factor‐β
Online Access:https://doi.org/10.1002/1878-0261.12162

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