High-throughput chromatin accessibility profiling at single-cell resolution

High-throughput chromatin accessibility profiling at single-cell resolution

Single-cell chromatin accessibility is a promising means to identify regulatory programs in mixtures of cells. Here the authors describe µ-ATAC-seq, a low-cost method that can generate thousands of accessibility profiles per day.

Bibliographic Details
Main Authors: Anja Mezger, Sandy Klemm, Ishminder Mann, Kara Brower, Alain Mir, Magnolia Bostick, Andrew Farmer, Polly Fordyce, Sten Linnarsson, William Greenleaf
Format: Article
Language:English
Published: Nature Publishing Group 2018-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-05887-x
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spelling doaj-af490554bcce4098a9e163206ed9a85f2021-05-11T10:04:16ZengNature Publishing GroupNature Communications2041-17232018-09-01911610.1038/s41467-018-05887-xHigh-throughput chromatin accessibility profiling at single-cell resolutionAnja Mezger0Sandy Klemm1Ishminder Mann2Kara Brower3Alain Mir4Magnolia Bostick5Andrew Farmer6Polly Fordyce7Sten Linnarsson8William Greenleaf9Department of Genetics, Stanford UniversityDepartment of Genetics, Stanford UniversityTakara Bio USADepartment of Bioengineering, Stanford UniversityTakara Bio USATakara Bio USATakara Bio USADepartment of Genetics, Stanford UniversityDepartment of Medical Biochemistry and Biophysics, Karolinska InstituteDepartment of Genetics, Stanford UniversitySingle-cell chromatin accessibility is a promising means to identify regulatory programs in mixtures of cells. Here the authors describe µ-ATAC-seq, a low-cost method that can generate thousands of accessibility profiles per day.https://doi.org/10.1038/s41467-018-05887-x
collection DOAJ
language English
format Article
sources DOAJ
author Anja Mezger
Sandy Klemm
Ishminder Mann
Kara Brower
Alain Mir
Magnolia Bostick
Andrew Farmer
Polly Fordyce
Sten Linnarsson
William Greenleaf
spellingShingle Anja Mezger
Sandy Klemm
Ishminder Mann
Kara Brower
Alain Mir
Magnolia Bostick
Andrew Farmer
Polly Fordyce
Sten Linnarsson
William Greenleaf
High-throughput chromatin accessibility profiling at single-cell resolution
Nature Communications
author_facet Anja Mezger
Sandy Klemm
Ishminder Mann
Kara Brower
Alain Mir
Magnolia Bostick
Andrew Farmer
Polly Fordyce
Sten Linnarsson
William Greenleaf
author_sort Anja Mezger
title High-throughput chromatin accessibility profiling at single-cell resolution
title_short High-throughput chromatin accessibility profiling at single-cell resolution
title_full High-throughput chromatin accessibility profiling at single-cell resolution
title_fullStr High-throughput chromatin accessibility profiling at single-cell resolution
title_full_unstemmed High-throughput chromatin accessibility profiling at single-cell resolution
title_sort high-throughput chromatin accessibility profiling at single-cell resolution
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-09-01
description Single-cell chromatin accessibility is a promising means to identify regulatory programs in mixtures of cells. Here the authors describe µ-ATAC-seq, a low-cost method that can generate thousands of accessibility profiles per day.
url https://doi.org/10.1038/s41467-018-05887-x
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