PD-L1 Is Expressed and Promotes the Expansion of Regulatory T Cells in Acute Myeloid Leukemia

PD-L1 Is Expressed and Promotes the Expansion of Regulatory T Cells in Acute Myeloid Leukemia

Intratumoral accumulation of CD4+CD25+Foxp3+ regulatory T (Treg) cells occurs in acute myeloid leukemia (AML), but little is known about the role of tumor cells themselves in this process. Here, we showed that an immune checkpoint PD-L1 expressed by AML cells promoted the conversion and expansion of...

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Bibliographic Details
Main Authors: Yuqing Dong, Yixiang Han, Yisha Huang, Songfu Jiang, Ziyang Huang, Rongrong Chen, Zhijie Yu, Kang Yu, Shenghui Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Immunology
Subjects:
acute myeloid leukemia
regulatory T cells
PD-L1
PD-1
interleukin-35
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01710/full

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