Cardiac specific PRMT1 ablation causes heart failure through CaMKII dysregulation

Cardiac specific PRMT1 ablation causes heart failure through CaMKII dysregulation

The mechanisms that regulate the activity of Ca2 +/calmodulin-dependent protein kinase II (CaMKII) in the context of heart failure are incompletely understood. Here the authors show that protein arginine methyltransferase 1 (PRMT1) prevents cardiac hyperactivation of CaMKII and heart failure develop...

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Main Authors: Jung-Hoon Pyun, Hyun-Ji Kim, Myong-Ho Jeong, Byeong-Yun Ahn, Tuan Anh Vuong, Dong I. Lee, Seri Choi, Seung-Hoi Koo, Hana Cho, Jong-Sun Kang
Format: Article
Language:English
Published: Nature Publishing Group 2018-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-07606-y
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spelling doaj-af3a2e76bb0b4a2582ff80e76159a01c2021-05-11T10:07:23ZengNature Publishing GroupNature Communications2041-17232018-11-019111510.1038/s41467-018-07606-yCardiac specific PRMT1 ablation causes heart failure through CaMKII dysregulationJung-Hoon Pyun0Hyun-Ji Kim1Myong-Ho Jeong2Byeong-Yun Ahn3Tuan Anh Vuong4Dong I. Lee5Seri Choi6Seung-Hoi Koo7Hana Cho8Jong-Sun Kang9Department of Molecular Cell Biology, Sungkyunkwan University School of MedicineSingle Cell Network Research Center, Sungkyunkwan University School of MedicineDepartment of Molecular Cell Biology, Sungkyunkwan University School of MedicineDepartment of Molecular Cell Biology, Sungkyunkwan University School of MedicineDepartment of Molecular Cell Biology, Sungkyunkwan University School of MedicineDivision of Cardiology, Department of Medicine, Johns Hopkins University School of MedicineDivision of Life Sciences, Korea UniversityDivision of Life Sciences, Korea UniversitySingle Cell Network Research Center, Sungkyunkwan University School of MedicineDepartment of Molecular Cell Biology, Sungkyunkwan University School of MedicineThe mechanisms that regulate the activity of Ca2 +/calmodulin-dependent protein kinase II (CaMKII) in the context of heart failure are incompletely understood. Here the authors show that protein arginine methyltransferase 1 (PRMT1) prevents cardiac hyperactivation of CaMKII and heart failure development by methylating CaMKII at arginine residues 9 and 275.https://doi.org/10.1038/s41467-018-07606-y
collection DOAJ
language English
format Article
sources DOAJ
author Jung-Hoon Pyun
Hyun-Ji Kim
Myong-Ho Jeong
Byeong-Yun Ahn
Tuan Anh Vuong
Dong I. Lee
Seri Choi
Seung-Hoi Koo
Hana Cho
Jong-Sun Kang
spellingShingle Jung-Hoon Pyun
Hyun-Ji Kim
Myong-Ho Jeong
Byeong-Yun Ahn
Tuan Anh Vuong
Dong I. Lee
Seri Choi
Seung-Hoi Koo
Hana Cho
Jong-Sun Kang
Cardiac specific PRMT1 ablation causes heart failure through CaMKII dysregulation
Nature Communications
author_facet Jung-Hoon Pyun
Hyun-Ji Kim
Myong-Ho Jeong
Byeong-Yun Ahn
Tuan Anh Vuong
Dong I. Lee
Seri Choi
Seung-Hoi Koo
Hana Cho
Jong-Sun Kang
author_sort Jung-Hoon Pyun
title Cardiac specific PRMT1 ablation causes heart failure through CaMKII dysregulation
title_short Cardiac specific PRMT1 ablation causes heart failure through CaMKII dysregulation
title_full Cardiac specific PRMT1 ablation causes heart failure through CaMKII dysregulation
title_fullStr Cardiac specific PRMT1 ablation causes heart failure through CaMKII dysregulation
title_full_unstemmed Cardiac specific PRMT1 ablation causes heart failure through CaMKII dysregulation
title_sort cardiac specific prmt1 ablation causes heart failure through camkii dysregulation
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-11-01
description The mechanisms that regulate the activity of Ca2 +/calmodulin-dependent protein kinase II (CaMKII) in the context of heart failure are incompletely understood. Here the authors show that protein arginine methyltransferase 1 (PRMT1) prevents cardiac hyperactivation of CaMKII and heart failure development by methylating CaMKII at arginine residues 9 and 275.
url https://doi.org/10.1038/s41467-018-07606-y
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