Selective Wnt/β-Catenin Pathway Activation Concomitant With Sustained Overexpression of miR-21 is Responsible for Aristolochic Acid-Induced AKI-to-CKD Transition

Selective Wnt/β-Catenin Pathway Activation Concomitant With Sustained Overexpression of miR-21 is Responsible for Aristolochic Acid-Induced AKI-to-CKD Transition

Acute kidney injury (AKI) is increasingly recognized as a cumulative risk factor for chronic kidney disease (CKD) progression. However, the underlying mechanisms remain unclear. Using an aristolochic acid (AA)-induced mouse model of AKI-to-CKD transition, we found that the development of tubulointer...

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Bibliographic Details
Main Authors: Qing Kuang, Sheng Wu, Ning Xue, Xiaoyan Wang, Xiaoqianq Ding, Yi Fang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Pharmacology
Subjects:
Wnt
β-catenin
miR-21
AKI-CKD transition
aristolochic acid
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.667282/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.667282/full

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