A New Chemoenzymatic Synthesis of the Chiral Key Intermediate of the Antiepileptic Brivaracetam

A New Chemoenzymatic Synthesis of the Chiral Key Intermediate of the Antiepileptic Brivaracetam

Brivaracetam is a new anticonvulsant compound, recently approved as an antiepileptic drug. This drug substance presents a 4-substituted pyrrolidone structure: the (4R)-configuration of the stereocenter present on the heterocyclic ring is the main target of the synthesis. The described method allows...

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Bibliographic Details
Main Authors: Samuele Ciceri, Paride Grisenti, Shahrzad Reza Elahi, Patrizia Ferraboschi
Format: Article
Language:English
Published: MDPI AG 2018-08-01
Series:Molecules
Subjects:
biocatalysis
lipase
irreversible transesterification
(3R)-3-propylbutyrolactone
Online Access:http://www.mdpi.com/1420-3049/23/9/2206

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