Evolution of a major drug metabolizing enzyme defect in the domestic cat and other felidae: phylogenetic timing and the role of hypercarnivory.

Evolution of a major drug metabolizing enzyme defect in the domestic cat and other felidae: phylogenetic timing and the role of hypercarnivory.

The domestic cat (Felis catus) shows remarkable sensitivity to the adverse effects of phenolic drugs, including acetaminophen and aspirin, as well as structurally-related toxicants found in the diet and environment. This idiosyncrasy results from pseudogenization of the gene encoding UDP-glucuronosy...

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Bibliographic Details
Main Authors: Binu Shrestha, J Michael Reed, Philip T Starks, Gretchen E Kaufman, Jared V Goldstone, Melody E Roelke, Stephen J O'Brien, Klaus-Peter Koepfli, Laurence G Frank, Michael H Court
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-03-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3065456?pdf=render

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