Orai1 mediates tumor-promoting store-operated Ca entry in human gastrointestinal stromal tumors via c-KIT and the extracellular signal–regulated kinase pathway

Orai1 mediates tumor-promoting store-operated Ca entry in human gastrointestinal stromal tumors via c-KIT and the extracellular signal–regulated kinase pathway

Gastrointestinal stromal tumors originate from interstitial cells of Cajal, the pacemaker cells of the gut. Ca 2+ regulates the pacemaker activity of interstitial cells of Cajal. Store-operated Ca 2+ entry mediates the majority of Ca 2+ entry in most cancer cells and may be a factor in regulating in...

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Bibliographic Details
Main Authors: Lei Wang, Jiaqi Hao, Yijian Zhang, Ziyi Yang, Yang Cao, Wei Lu, Yijun Shu, Lin Jiang, Yunping Hu, Wenjie Lv, Yingbin Liu, Ping Dong
Format: Article
Language:English
Published: IOS Press 2017-02-01
Series:Tumor Biology
Online Access:https://doi.org/10.1177/1010428317691426

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